About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:release of cytochrome c from mitochondria
GO id:GO:0001836
Definition:The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
CommentsThe release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011.
Number of paths to term: 17

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aapoptotic signaling pathway
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                                negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                                positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                                regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-acellular component organization or biogenesis
                        is-acellular component organization
                                is-aorganelle organization
                                        is-amitochondrion organization
                                                is-aapoptotic mitochondrial changes
                                                        is-amitochondrial fragmentation involved in apoptotic process
                                                        is-aregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        is-arelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                                negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                                positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                                regulatesregulation of release of cytochrome c from mitochondria +
                                                        is-arelease of matrix enzymes from mitochondria


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                        regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-aorganelle organization
                                is-amitochondrion organization
                                        is-aapoptotic mitochondrial changes
                                                is-amitochondrial fragmentation involved in apoptotic process
                                                is-aregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                is-arelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                        regulatesregulation of release of cytochrome c from mitochondria +
                                                is-arelease of matrix enzymes from mitochondria


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                        regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                                negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                                positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                                regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic mitochondrial changes
                                                                is-amitochondrial fragmentation involved in apoptotic process
                                                                is-aregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                                is-arelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                                        regulatesregulation of release of cytochrome c from mitochondria +
                                                                is-arelease of matrix enzymes from mitochondria


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway +
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                                        regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                        regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                        regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                        regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic mitochondrial changes
                                                                is-amitochondrial fragmentation involved in apoptotic process
                                                                is-aregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                                is-arelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                                        regulatesregulation of release of cytochrome c from mitochondria +
                                                                is-arelease of matrix enzymes from mitochondria


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway +
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                                        regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                        regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                                negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                                positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                                regulatesregulation of release of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic mitochondrial changes
                                                                is-amitochondrial fragmentation involved in apoptotic process
                                                                is-aregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                                is-arelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                                        regulatesregulation of release of cytochrome c from mitochondria +
                                                                is-arelease of matrix enzymes from mitochondria


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway +
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria [GO:0001836] (52 genes, 73 annotations)
                                                                        negatively-regulatesnegative regulation of release of cytochrome c from mitochondria
                                                                        positively-regulatespositive regulation of release of cytochrome c from mitochondria
                                                                        regulatesregulation of release of cytochrome c from mitochondria +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory