| GO term: | release of cytochrome c from mitochondria |
| GO id: | GO:0001836 |
| Definition: | The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. |
| Comments | The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. |
| Number of paths to term: | 36 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
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membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria [GO:0001836] (49 genes, 66 annotations)negative regulation of release of cytochrome c from mitochondriapositive regulation of release of cytochrome c from mitochondriaregulation of release of cytochrome c from mitochondria +biological_processsingle-organism processdeathcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of 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annotations)negative regulation of release of cytochrome c from mitochondriapositive regulation of release of cytochrome c from mitochondriaregulation of release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic mitochondrial changesmitochondrial fragmentation involved in apoptotic processmitochondrial outer membrane permeabilization +release of cytochrome c from mitochondria [GO:0001836] (49 genes, 66 annotations)negative regulation of release of cytochrome c from mitochondriapositive regulation of release of cytochrome c from mitochondriaregulation of release of cytochrome c from mitochondria +release of matrix enzymes from mitochondriabiological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic 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pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria [GO:0001836] (49 genes, 66 annotations)negative regulation of release of cytochrome c from mitochondriapositive regulation of release of cytochrome c from mitochondriaregulation of release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria [GO:0001836] (49 genes, 66 annotations)negative regulation of release of cytochrome c from mitochondriapositive regulation of release of cytochrome c from mitochondriaregulation of release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria [GO:0001836] (49 genes, 66 annotations)negative regulation of release of cytochrome c from mitochondriapositive regulation of release of cytochrome c from mitochondriaregulation of release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria [GO:0001836] (49 genes, 66 annotations)negative regulation of release of cytochrome c from mitochondriapositive regulation of release of cytochrome c from mitochondriaregulation of release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria [GO:0001836] (49 genes, 66 annotations)negative regulation of release of cytochrome c from mitochondriapositive regulation of release of cytochrome c from mitochondriaregulation of release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processorganelle organizationmitochondrion organizationapoptotic mitochondrial changesmitochondrial fragmentation involved in apoptotic processmitochondrial outer membrane permeabilization +release of cytochrome c from mitochondria [GO:0001836] (49 genes, 66 annotations)negative regulation of release of cytochrome c from mitochondriapositive regulation of release of cytochrome c from mitochondriaregulation of release of cytochrome c from mitochondria +release of matrix enzymes from mitochondriaMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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