Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATP8B1
  • Mouse genes Atp8b1
  • Rat genes Atp8b1
  • Zfish genes atp8b1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atp8b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015247	aminophospholipid flippase activity	Atp8b1	IDA		Mouse	MGI:MGI:5908789|PMID:20510206
Molecular Function	GO:1901612	cardiolipin binding	Atp8b1	IDA		Mouse	PMID:20852622
Molecular Function	GO:0005319	lipid transporter activity	Atp8b1	IMP		Mouse	PMID:20852622
Molecular Function	GO:0140345	phosphatidylcholine flippase activity	ATP8B1	IDA		Human	PMID:25315773
Molecular Function	GO:0140345	phosphatidylcholine flippase activity	ATP8B1	IDA		Human	PMID:25947375
Molecular Function	GO:0140346	phosphatidylserine flippase activity	Atp8b1	IMP		Rat	PMID:19027009|RGD:39458026
Molecular Function	GO:0005515	protein binding	ATP8B1	IPI	UniProtKB:Q9NV96	Human	PMID:19731236
Molecular Function	GO:0005515	protein binding	ATP8B1	IPI	UniProtKB:Q3MIR4	Human	PMID:20947505
Molecular Function	GO:0005515	protein binding	ATP8B1	IPI	UniProtKB:Q9NV96	Human	PMID:20947505
Molecular Function	GO:0005515	protein binding	ATP8B1	IPI	UniProtKB:Q3MIR4	Human	PMID:20961850
Molecular Function	GO:0005515	protein binding	ATP8B1	IPI	UniProtKB:Q9NV96	Human	PMID:20961850
Molecular Function	GO:0005515	protein binding	ATP8B1	IPI	UniProtKB:Q3MIR4	Human	PMID:21914794
Molecular Function	GO:0005515	protein binding	ATP8B1	IPI	UniProtKB:Q9NV96	Human	PMID:21914794
Molecular Function	GO:0005515	protein binding	ATP8B1	IPI	UniProtKB:Q9NV96	Human	PMID:25239307
Molecular Function	GO:0005515	protein binding	ATP8B1	IPI	UniProtKB:Q9NV96	Human	PMID:25947375
Cellular Component	GO:0016324	apical plasma membrane	ATP8B1	IDA		Human	PMID:11682026
Cellular Component	GO:0016324	apical plasma membrane	ATP8B1	IDA		Human	PMID:20512993
Cellular Component	GO:0031526	brush border membrane	Atp8b1	IDA		Rat	PMID:11584374|RGD:1599400
Cellular Component	GO:0005829	cytosol	ATP8B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	ATP8B1	IDA		Human	PMID:21914794
Cellular Component	GO:0005794	Golgi apparatus	ATP8B1	IDA		Human	PMID:20947505
Cellular Component	GO:0016020	membrane	Atp8b1	IDA		Rat	PMID:11682026|RGD:1581818
Cellular Component	GO:0016604	nuclear body	ATP8B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ATP8B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:1990531	phospholipid-translocating ATPase complex	ATP8B1	IPI		Human	PMID:20961850
Cellular Component	GO:1990531	phospholipid-translocating ATPase complex	ATP8B1	IDA		Human	PMID:25239307
Cellular Component	GO:1990531	phospholipid-translocating ATPase complex	ATP8B1	IDA		Human	PMID:25947375
Cellular Component	GO:0005886	plasma membrane	ATP8B1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ATP8B1	IDA		Human	PMID:20947505
Cellular Component	GO:0005886	plasma membrane	ATP8B1	IDA		Human	PMID:25315773
Cellular Component	GO:0005886	plasma membrane	Atp8b1	IDA		Mouse	MGI:MGI:5908789|PMID:20510206
Cellular Component	GO:0005886	plasma membrane	Atp8b1	IDA		Mouse	PMID:20852622
Cellular Component	GO:0032420	stereocilium	Atp8b1	IDA		Mouse	MGI:MGI:3849653|PMID:19478059
Biological Process	GO:0015917	aminophospholipid transport	Atp8b1	IDA		Mouse	MGI:MGI:5908789|PMID:20510206
Biological Process	GO:0045176	apical protein localization	ATP8B1	IMP		Human	PMID:27301931
Biological Process	GO:0015721	bile acid and bile salt transport	Atp8b1	IMP		Mouse	MGI:MGI:3847570|PMID:19228692
Biological Process	GO:0008206	bile acid metabolic process	Atp8b1	IMP	MGI:MGI:3043815	Mouse	PMID:14976163
Biological Process	GO:0060119	inner ear receptor cell development	Atp8b1	IMP		Mouse	MGI:MGI:3849653|PMID:19478059
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ATP8B1	IMP		Human	PMID:16628629
Biological Process	GO:0015711	organic anion transport	Atp8b1	IMP		Mouse	MGI:MGI:3847570|PMID:19228692
Biological Process	GO:0045332	phospholipid translocation	ATP8B1	IDA		Human	PMID:20510206
Biological Process	GO:2001225	regulation of chloride transport	ATP8B1	IMP		Human	PMID:27301931
Biological Process	GO:0032534	regulation of microvillus assembly	ATP8B1	IMP		Human	PMID:20512993
Biological Process	GO:1903729	regulation of plasma membrane organization	Atp8b1	IMP		Mouse	MGI:MGI:5701547|PMID:26416959
Biological Process	GO:0007605	sensory perception of sound	Atp8b1	IMP		Mouse	MGI:MGI:3849653|PMID:19478059
Biological Process	GO:0021650	vestibulocochlear nerve formation	Atp8b1	IMP		Mouse	MGI:MGI:3849653|PMID:19478059
Biological Process	GO:0006855	xenobiotic transmembrane transport	ATP8B1	IDA		Human	PMID:20510206

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern