Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATOH8
  • Mouse genes Atoh8
  • Rat genes Atoh8
  • Zfish genes atoh8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atoh8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ATOH8	IDA		Human	PMID:24236640
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Atoh8	IDA		Mouse	MGI:MGI:5569451|PMID:23938248
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Atoh8	IPI	UniProtKB:Q60867	Mouse	MGI:MGI:3798332|PMID:18560595
Molecular Function	GO:0070888	E-box binding	ATOH8	IDA		Human	PMID:24236640
Molecular Function	GO:0008134	transcription factor binding	Atoh8	IPI	UniProtKB:P15806	Mouse	MGI:MGI:5569451|PMID:23938248
Molecular Function	GO:0008134	transcription factor binding	Atoh8	IPI	UniProtKB:Q08369|UniProtKB:Q8CCH7	Mouse	MGI:MGI:5527043|PMID:23836893
Molecular Function	GO:0008134	transcription factor binding	Atoh8	IPI	UniProtKB:P70661	Mouse	MGI:MGI:3798332|PMID:18560595
Cellular Component	GO:0005737	cytoplasm	Atoh8	IDA		Mouse	MGI:MGI:5634879|PMID:24186058
Cellular Component	GO:0005654	nucleoplasm	ATOH8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ATOH8	IDA		Human	PMID:24463812
Cellular Component	GO:0005634	nucleus	Atoh8	IDA		Mouse	MGI:MGI:5634879|PMID:24186058
Biological Process	GO:0001704	formation of primary germ layer	Atoh8	IMP		Mouse	MGI:MGI:3798332|PMID:18560595
Biological Process	GO:0007507	heart development	atoh8	IGI	ZFIN:ZDB-MRPHLNO-051128-1,ZFIN:ZDB-MRPHLNO-170314-2	Zfish	PMID:23836893
Biological Process	GO:0007507	heart development	atoh8	IGI	ZFIN:ZDB-MRPHLNO-081114-1,ZFIN:ZDB-MRPHLNO-170314-2	Zfish	PMID:23836893
Biological Process	GO:0001947	heart looping	atoh8	IMP		Zfish	PMID:23836893|ZFIN:ZDB-PUB-170314-14
Biological Process	GO:0001947	heart looping	atoh8	IMP	ZFIN:ZDB-MRPHLNO-170314-2	Zfish	PMID:23836893
Biological Process	GO:0001947	heart looping	atoh8	IMP	ZFIN:ZDB-MRPHLNO-170420-2	Zfish	PMID:23836893
Biological Process	GO:0001947	heart looping	atoh8	IMP	ZFIN:ZDB-MRPHLNO-170314-2,ZFIN:ZDB-MRPHLNO-170420-1,ZFIN:ZDB-MRPHLNO-170420-2	Zfish	PMID:23836893
Biological Process	GO:0001947	heart looping	atoh8	IMP	ZFIN:ZDB-MRPHLNO-170420-1	Zfish	PMID:23836893
Biological Process	GO:0051450	myoblast proliferation	Atoh8	IDA		Mouse	MGI:MGI:5634879|PMID:24186058
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Atoh8	IDA		Mouse	MGI:MGI:5569451|PMID:23938248
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Atoh8	IDA		Mouse	MGI:MGI:3798332|PMID:18560595
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ATOH8	IMP		Human	PMID:24463812
Biological Process	GO:0010629	negative regulation of gene expression	ATOH8	IMP		Human	PMID:27780851
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ATOH8	IDA		Human	PMID:24236640
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation	ATOH8	IDA		Human	PMID:24463812
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation	ATOH8	IMP		Human	PMID:24463812
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ATOH8	IMP		Human	PMID:24463812
Biological Process	GO:1902895	positive regulation of miRNA transcription	ATOH8	IGI	UniProtKB:P23769	Human	PMID:27780851
Biological Process	GO:0061074	regulation of neural retina development	atoh8	IMP	ZFIN:ZDB-MRPHLNO-100624-1	Zfish	PMID:20532172
Biological Process	GO:0061074	regulation of neural retina development	atoh8	IMP	ZFIN:ZDB-MRPHLNO-100624-2	Zfish	PMID:20532172
Biological Process	GO:2001014	regulation of skeletal muscle cell differentiation	atoh8	IMP	ZFIN:ZDB-MRPHLNO-100624-1	Zfish	PMID:20532172
Biological Process	GO:2001014	regulation of skeletal muscle cell differentiation	atoh8	IMP	ZFIN:ZDB-MRPHLNO-100624-2	Zfish	PMID:20532172
Biological Process	GO:0060395	SMAD protein signal transduction	ATOH8	IDA		Human	PMID:24236640
Biological Process	GO:0048797	swim bladder formation	atoh8	IMP		Zfish	PMID:23836893|ZFIN:ZDB-PUB-170314-14
Biological Process	GO:0048797	swim bladder formation	atoh8	IGI	ZFIN:ZDB-MRPHLNO-051128-1,ZFIN:ZDB-MRPHLNO-170314-2	Zfish	PMID:23836893
Biological Process	GO:0048797	swim bladder formation	atoh8	IMP	ZFIN:ZDB-MRPHLNO-170314-2	Zfish	PMID:23836893
Biological Process	GO:0035148	tube formation	ATOH8	IMP		Human	PMID:24463812

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern