Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ASTL
  • Mouse genes Astl
  • Rat genes Astl
  • Zfish genes c6ast1,c6ast3,c6ast4,hce2l1,npsn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Astl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070001	aspartic-type peptidase activity	Astl	IDA		Mouse	MGI:MGI:5427546|PMID:22472438
Molecular Function	GO:0070002	glutamic-type peptidase activity	Astl	IDA		Mouse	MGI:MGI:5427546|PMID:22472438
Molecular Function	GO:0008233	peptidase activity	Astl	IDA		Mouse	MGI:MGI:5316357|PMID:22206759
Molecular Function	GO:0005515	protein binding	ASTL	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Astl	IPI	UniProtKB:Q9D9X8	Mouse	MGI:MGI:5316357|PMID:22206759
Cellular Component	GO:0060473	cortical granule	Astl	IDA		Mouse	MGI:MGI:5427546|PMID:22472438
Cellular Component	GO:0005737	cytoplasm	Astl	IDA		Mouse	MGI:MGI:5316357|PMID:22206759
Cellular Component	GO:0005886	plasma membrane	Astl	IDA		Mouse	MGI:MGI:5316357|PMID:22206759
Biological Process	GO:0007155	cell adhesion	Astl	IMP		Mouse	MGI:MGI:5316357|PMID:22206759
Biological Process	GO:0042742	defense response to bacterium	npsn	IMP	ZFIN:ZDB-GENO-190430-8	Zfish	PMID:28835569
Biological Process	GO:0009566	fertilization	Astl	IMP		Mouse	MGI:MGI:5316357|PMID:22206759
Biological Process	GO:2000360	negative regulation of binding of sperm to zona pellucida	Astl	IDA		Mouse	MGI:MGI:5427546|PMID:22472438
Biological Process	GO:0010954	positive regulation of protein processing	Astl	IDA		Mouse	MGI:MGI:5427546|PMID:22472438
Biological Process	GO:0060468	prevention of polyspermy	Astl	IDA		Mouse	MGI:MGI:5427546|PMID:22472438

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern