Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ARX
  • Mouse genes Arx
  • Rat genes Arx
  • Zfish genes arxa,arxb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Arx	IDA		Mouse	PMID:21966449
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ARX	IDA		Human	PMID:31691806
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ARX	IDA		Human	PMID:16301625
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ARX	IDA		Human	PMID:22194193
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Arx	IDA		Mouse	MGI:MGI:3579957|PMID:15930104
Molecular Function	GO:0005515	protein binding	ARX	IPI	UniProtKB:P12814	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	ARX	IPI	UniProtKB:Q9NRD5	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	ARX	IPI	UniProtKB:Q9UPP1	Human	PMID:34356104
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ARX	IDA		Human	PMID:22194193
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ARX	IDA		Human	PMID:31691806
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Arx	IDA		Mouse	MGI:MGI:3579957|PMID:15930104
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ARX	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	ARX	IDA		Human	PMID:22194193
Cellular Component	GO:0005634	nucleus	ARX	IDA		Human	PMID:31691806
Cellular Component	GO:0005634	nucleus	Arx	IDA		Rat	PMID:18509041|RGD:11565456
Biological Process	GO:0007411	axon guidance	Arx	IMP		Mouse	PMID:15677725
Biological Process	GO:0007411	axon guidance	Arx	IMP	MGI:MGI:2679972	Mouse	PMID:17460091
Biological Process	GO:0007420	brain development	Arx	IEP		Rat	PMID:14992814|RGD:11565457
Biological Process	GO:0021846	cell proliferation in forebrain	Arx	IMP	MGI:MGI:2429693	Mouse	PMID:15677725
Biological Process	GO:0021853	cerebral cortex GABAergic interneuron migration	Arx	IMP	MGI:MGI:2679972	Mouse	PMID:17460091
Biological Process	GO:0021800	cerebral cortex tangential migration	Arx	IMP	MGI:MGI:2679972	Mouse	PMID:17460091
Biological Process	GO:0021831	embryonic olfactory bulb interneuron precursor migration	Arx	IMP	MGI:MGI:2429693	Mouse	PMID:15677725
Biological Process	GO:0072148	epithelial cell fate commitment	Arx	IMP	MGI:MGI:3803178	Mouse	PMID:22387004
Biological Process	GO:0030900	forebrain development	Arx	IMP	MGI:MGI:2429693	Mouse	PMID:12379852
Biological Process	GO:0021759	globus pallidus development	Arx	IMP	MGI:MGI:2679972	Mouse	PMID:17460091
Biological Process	GO:1904936	interneuron migration	Arx	IMP	MGI:MGI:2429693	Mouse	PMID:12379852
Biological Process	GO:0044241	lipid digestion	Arx	IMP	MGI:MGI:3803178	Mouse	PMID:22387004
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ARX	IDA		Human	PMID:22194193
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Arx	IDA		Mouse	MGI:MGI:3579957|PMID:15930104
Biological Process	GO:0048666	neuron development	Arx	IEP		Rat	PMID:14992814|RGD:11565457
Biological Process	GO:0048666	neuron development	arxa	IMP	ZFIN:ZDB-MRPHLNO-120911-6	Zfish	PMID:22728160
Biological Process	GO:0001764	neuron migration	Arx	IMP	MGI:MGI:2429693	Mouse	PMID:12379852
Biological Process	GO:0001764	neuron migration	Arx	IMP	MGI:MGI:2679972	Mouse	PMID:17460091
Biological Process	GO:0021772	olfactory bulb development	Arx	IMP	MGI:MGI:2429693	Mouse	PMID:15677725
Biological Process	GO:0035265	organ growth	Arx	IMP	MGI:MGI:2429693	Mouse	PMID:15677725
Biological Process	GO:0003322	pancreatic A cell development	arxa	IMP	ZFIN:ZDB-MRPHLNO-130327-1	Zfish	PMID:23244389
Biological Process	GO:0010628	positive regulation of gene expression	Arx	IMP		Mouse	PMID:23246292
Biological Process	GO:0046622	positive regulation of organ growth	Arx	IMP	MGI:MGI:2429693	Mouse	PMID:15677725
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ARX	IDA		Human	PMID:31691806
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ARX	IGI	UniProtKB:Q9UPP1	Human	PMID:31691806
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Arx	IMP		Mouse	MGI:MGI:7339311|PMID:31691806
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Arx	IMP	MGI:MGI:2429693	Mouse	PMID:12379852
Biological Process	GO:0021539	subthalamus development	arxa	IMP	ZFIN:ZDB-MRPHLNO-120911-6	Zfish	PMID:22728160
Biological Process	GO:0021537	telencephalon development	arxa	IMP	ZFIN:ZDB-MRPHLNO-130327-1,ZFIN:ZDB-MRPHLNO-130327-2	Zfish	PMID:26337422
Biological Process	GO:0021794	thalamus development	arxa	IMP	ZFIN:ZDB-MRPHLNO-130327-1,ZFIN:ZDB-MRPHLNO-130327-2	Zfish	PMID:26337422

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern