Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ARHGEF5
  • Mouse genes Arhgef5
  • Rat genes Arhgef5
  • Zfish genes arhgef5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arhgef5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ARHGEF5	IDA		Human	PMID:15601624
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:P62993	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:P62993	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:P14373	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q13137	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q5JST6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q96EW2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q9BYV2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:A1E959	Human	PMID:25911094
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q9Y2V7	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:P62993	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:P62993	Human	PMID:32203420
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:O15160	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:P14373	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:P15884-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:P25791-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q58EX7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q5JST6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q7L775	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q8IYB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q8ND83	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q96EW2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q96KN4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q9BYV2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q9NVG8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q9UGI0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q9UJV3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:Q9Y2V7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF5	IPI	UniProtKB:P07947	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Arhgef5	IPI	PR:P05480	Mouse	PMID:21525037
Cellular Component	GO:0071944	cell periphery	ARHGEF5	IDA		Human	PMID:25911094
Cellular Component	GO:0005737	cytoplasm	ARHGEF5	IDA		Human	PMID:14662653
Cellular Component	GO:0005829	cytosol	ARHGEF5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ARHGEF5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ARHGEF5	IDA		Human	PMID:14662653
Cellular Component	GO:0005886	plasma membrane	ARHGEF5	IDA		Human	GO_REF:0000052
Biological Process	GO:0030036	actin cytoskeleton organization	Arhgef5	IDA		Mouse	PMID:21525037
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Arhgef5	IMP		Mouse	PMID:26880577
Biological Process	GO:0002408	myeloid dendritic cell chemotaxis	Arhgef5	IMP		Mouse	PMID:19713215
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ARHGEF5	IDA		Human	PMID:15601624
Biological Process	GO:0043547	positive regulation of GTPase activity	Arhgef5	IDA		Mouse	PMID:21525037
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ARHGEF5	IDA		Human	PMID:15601624
Biological Process	GO:0071803	positive regulation of podosome assembly	Arhgef5	IGI	MGI:MGI:98397	Mouse	PMID:21525037
Biological Process	GO:0071803	positive regulation of podosome assembly	Arhgef5	IGI	MGI:MGI:1096342	Mouse	PMID:21525037
Biological Process	GO:1904591	positive regulation of protein import	ARHGEF5	IMP		Human	PMID:15601624
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ARHGEF5	IMP		Human	PMID:15601624
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ARHGEF5	IMP		Human	PMID:14662653
Biological Process	GO:0051493	regulation of cytoskeleton organization	ARHGEF5	IMP		Human	PMID:15601624
Biological Process	GO:0043087	regulation of GTPase activity	ARHGEF5	IDA		Human	PMID:21525037

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern