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Arhgef5
Gene Detail
Symbol

Name
ID
Arhgef5
Rho guanine nucleotide exchange factor (GEF) 5
MGI:1858952
Synonyms
2210412D05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
21.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:43265582-43289320 bp, + strand
From VEGA annotation of GRCm38

  23739 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:66300  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Arhgef5

Human
homologs
Human Homolog ARHGEF5, Rho guanine nucleotide exchange factor (GEF) 5
NCBI Gene ID 7984
neXtProt AC  NX_Q12774
Human Synonyms  GEF5, P60, TIM, TIM1
Human Chr (Location)  7q35; chr7:144355341-144380632 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased Th2 response in an ovalbumin-induced asthma model.
 
Interactions
Arhgef5 interacts with 160 markers (Mir15b, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process actin cytoskeleton organization, myeloid dendritic cell chemotaxis, ...
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(60)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(61) Genomic(1) cDNA(60)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000043554 (Evidence)
Ensembl Gene ModelENSMUSG00000033542 (Evidence)
Entrez Gene54324 (Evidence)
UniGene320978
DFCITC1601234, TC1599256, TC1629656, TC1601945, TC1713041
DoTSDT.110492720, DT.91579091, DT.55137501, DT.528935, DT.97388911
Consensus CDS ProjectCCDS51759.1
International Mouse Knockout Project StatusArhgef5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043554 VEGA Gene Model | MGI Sequence Detail 23739 C57BL/6J ±  kb
transcript OTTMUST00000114331 VEGA | MGI Sequence Detail 5469 Not Applicable 
polypeptide OTTMUSP00000063810 VEGA | MGI Sequence Detail 1581 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(10)
Polymorphisms
SNPs within 2kb(202 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000004258 rho guanine nucleotide exchange factor 5
References
(Earliest) J:62157 Thomas JW, et al., Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 2000 May;10(5):624-33
(Latest) J:182942 Kuroiwa M, et al., The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation. J Cell Sci. 2011 May 15;124(Pt 10):1726-38
All references(29)
Other
accession IDs
MGI:1919632, MGI:2141687

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory