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Arhgef5 Gene Detail
Summary
  • Symbol
    Arhgef5
  • Name
    Rho guanine nucleotide exchange factor (GEF) 5
  • Synonyms
    2210412D05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858952
    NCBI Gene: 54324
  • Gene Overview
    MyGene.info: ARHGEF5
Location & Maps
more
  • Sequence Map
    Chr6:43265582-43289320 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23739 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 21.15 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ARHGEF5, Rho guanine nucleotide exchange factor 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ARHGEF5, Rho guanine nucleotide exchange factor 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GEF5, P60, TIM, TIM1
  • Links
    NCBI Gene ID: 7984
    neXtProt AC: NX_Q12774

  • Chr Location
    7q35; chr7:144355396-144380632 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased Th2 response in an ovalbumin-induced asthma model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043554 VEGA Gene Model | MGI Sequence Detail 23739 C57BL/6J ±  kb
transcript OTTMUST00000114331 VEGA | MGI Sequence Detail 5469 Not Applicable  
polypeptide OTTMUSP00000063810 VEGA | MGI Sequence Detail 1581 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    201 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004258 rho guanine nucleotide exchange factor 5
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR029212 Rho guanine nucleotide exchange factor 5/35, N-terminal
    IPR001452 SH3 domain
Molecular
Reagents
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  • All nucleic 61
    Genomic 1
    cDNA 60

    Microarray probesets 4
Other
Accession IDs
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MGI:1919632, MGI:2141687
References
more
  • Summaries
    All 32
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:62157 Thomas JW, et al., Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 2000 May;10(5):624-33
  • Latest
    J:220966 Mandel-Brehm C, et al., Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5129-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory