Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ARHGEF12
  • Mouse genes Arhgef12
  • Rat genes Arhgef12
  • Zfish genes arhgef12a,arhgef12b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arhgef12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	ARHGEF12	IDA		Human	PMID:15755723
Molecular Function	GO:0005515	protein binding	ARHGEF12	IPI	UniProtKB:P08069	Human	PMID:11724822
Molecular Function	GO:0005515	protein binding	ARHGEF12	IPI	UniProtKB:P61586	Human	PMID:15364580
Molecular Function	GO:0005515	protein binding	ARHGEF12	IPI	UniProtKB:P61793	Human	PMID:15755723
Molecular Function	GO:0005515	protein binding	ARHGEF12	IPI	UniProtKB:P61586	Human	PMID:20300064
Molecular Function	GO:0005515	protein binding	ARHGEF12	IPI	UniProtKB:Q8N6F7	Human	PMID:20844236
Molecular Function	GO:0005515	protein binding	Arhgef12	IPI	UniProtKB:Q8CJH3	Mouse	MGI:MGI:5297297|PMID:22019888
Molecular Function	GO:0005515	protein binding	Arhgef12	IPI	UniProtKB:Q8CJH3	Mouse	MGI:MGI:5508282|PMID:12123608
Cellular Component	GO:0005737	cytoplasm	ARHGEF12	IDA		Human	PMID:15755723
Cellular Component	GO:0070062	extracellular exosome	ARHGEF12	HDA		Human	PMID:19056867
Biological Process	GO:0030218	erythrocyte differentiation	arhgef12b	IGI	ZFIN:ZDB-MRPHLNO-200915-1,ZFIN:ZDB-MRPHLNO-200915-2	Zfish	PMID:31467124
Biological Process	GO:0030218	erythrocyte differentiation	arhgef12a	IGI	ZFIN:ZDB-MRPHLNO-200915-1,ZFIN:ZDB-MRPHLNO-200915-2	Zfish	PMID:31467124
Biological Process	GO:0030218	erythrocyte differentiation	arhgef12a	IGI	ZFIN:ZDB-GENO-220829-3	Zfish	PMID:31467124
Biological Process	GO:0030218	erythrocyte differentiation	arhgef12b	IGI	ZFIN:ZDB-GENO-220829-3	Zfish	PMID:31467124
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ARHGEF12	IDA		Human	PMID:15755723
Biological Process	GO:0008217	regulation of blood pressure	Arhgef12	IMP		Mouse	PMID:26531127

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern