Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APC2
  • Mouse genes Apc2
  • Rat genes Apc2
  • Zfish genes apc2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	APC2	IDA		Human	PMID:9823329
Molecular Function	GO:0005515	protein binding	APC2	IPI	UniProtKB:Q15691	Human	PMID:10644998
Molecular Function	GO:0005515	protein binding	APC2	IPI	UniProtKB:Q9UPY8	Human	PMID:10644998
Molecular Function	GO:0005515	protein binding	APC2	IPI	UniProtKB:Q9UPY8-1	Human	PMID:10644998
Molecular Function	GO:0005515	protein binding	APC2	IPI	UniProtKB:Q13625	Human	PMID:10646860
Cellular Component	GO:0005884	actin filament	APC2	IDA		Human	PMID:11691822
Cellular Component	GO:0016342	catenin complex	APC2	IDA		Human	PMID:9823329
Cellular Component	GO:0005737	cytoplasm	APC2	IDA		Human	PMID:11691822
Cellular Component	GO:0005881	cytoplasmic microtubule	APC2	IDA		Human	PMID:10644998
Cellular Component	GO:0005881	cytoplasmic microtubule	APC2	IDA		Human	PMID:11691822
Cellular Component	GO:0005881	cytoplasmic microtubule	APC2	IDA		Human	PMID:25753423
Cellular Component	GO:0005829	cytosol	APC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	APC2	IDA		Human	PMID:11691822
Cellular Component	GO:0045171	intercellular bridge	APC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031258	lamellipodium membrane	APC2	IDA		Human	PMID:11691822
Cellular Component	GO:0015630	microtubule cytoskeleton	APC2	IDA		Human	PMID:10644998
Cellular Component	GO:0030496	midbody	APC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	APC2	IDA		Human	PMID:10644998
Cellular Component	GO:0048471	perinuclear region of cytoplasm	APC2	IDA		Human	PMID:10646860
Cellular Component	GO:0048471	perinuclear region of cytoplasm	APC2	IDA		Human	PMID:11691822
Cellular Component	GO:0098794	postsynapse	Apc2	IDA		Rat	PMID:21186356|RGD:13702406
Biological Process	GO:0090630	activation of GTPase activity	APC2	IMP		Human	PMID:25753423
Biological Process	GO:0000226	microtubule cytoskeleton organization	APC2	IMP		Human	PMID:25753423
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	APC2	IDA		Human	PMID:10021369
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	APC2	IMP		Human	PMID:26393419
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	APC2	IDA		Human	PMID:9823329

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern