Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AP2A1
  • Mouse genes Ap2a1
  • Rat genes Ap2a1
  • Zfish genes ap2a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ap2a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	AP2A1	IPI	UniProtKB:Q07954	Human	PMID:26005850
Molecular Function	GO:0005515	protein binding	AP2A1	IPI	UniProtKB:Q13492	Human	PMID:16262731
Molecular Function	GO:0005515	protein binding	AP2A1	IPI	UniProtKB:Q04671	Human	PMID:19116314
Molecular Function	GO:0005515	protein binding	AP2A1	IPI	UniProtKB:O95342	Human	PMID:22262466
Molecular Function	GO:0005515	protein binding	AP2A1	IPI	UniProtKB:O14672,UniProtKB:O94973,UniProtKB:P63010,UniProtKB:Q96CW1	Human	PMID:23676497
Molecular Function	GO:0005515	protein binding	Ap2a1	IPI	UniProtKB:Q9CR95	Mouse	MGI:MGI:3688370|PMID:14555962
Molecular Function	GO:0005515	protein binding	Ap2a1	IPI	UniProtKB:O35598,UniProtKB:P17427,UniProtKB:P84091,UniProtKB:Q9DBG3	Mouse	MGI:MGI:5514106|PMID:23676497
Molecular Function	GO:0005515	protein binding	Ap2a1	IPI	UniProtKB:Q01097	Mouse	MGI:MGI:3701026|PMID:16710293
Molecular Function	GO:0005515	protein binding	Ap2a1	IPI	UniProtKB:Q8VD37	Mouse	MGI:MGI:4887327|PMID:17626015
Molecular Function	GO:0005515	protein binding	Ap2a1	IPI	RGD:620225	Rat	PMID:11423532|RGD:1579732
Molecular Function	GO:0005515	protein binding	Ap2a1	IPI	RGD:1602726	Rat	PMID:12213833|RGD:1303953
Molecular Function	GO:0005515	protein binding	Ap2a1	IPI	RGD:1313643	Rat	PMID:9920862|RGD:9685534
Molecular Function	GO:0019901	protein kinase binding	Ap2a1	IPI	UniProtKB:Q5S007	Mouse	MGI:MGI:4941068|PMID:21307259
Molecular Function	GO:0044877	protein-containing complex binding	Ap2a1	IPI	RGD:620646	Rat	PMID:23719817|RGD:9491749
Molecular Function	GO:0044877	protein-containing complex binding	Ap2a1	IPI	RGD:71015	Rat	PMID:23719817|RGD:9491749
Cellular Component	GO:0030122	AP-2 adaptor complex	AP2A1	IDA		Human	PMID:23676497
Cellular Component	GO:0030122	AP-2 adaptor complex	Ap2a1	IDA		Mouse	MGI:MGI:5514106|PMID:23676497
Cellular Component	GO:0016324	apical plasma membrane	Ap2a1	IDA		Rat	PMID:12703553|RGD:2306444
Cellular Component	GO:0016323	basolateral plasma membrane	Ap2a1	IDA		Rat	PMID:12703553|RGD:2306444
Cellular Component	GO:0030136	clathrin-coated vesicle	Ap2a1	IDA		Rat	PMID:11889126|RGD:708337
Cellular Component	GO:0032433	filopodium tip	Ap2a1	IDA		Mouse	PMID:24305805
Cellular Component	GO:0016020	membrane	AP2A1	HDA		Human	PMID:19946888
Cellular Component	GO:0030117	membrane coat	Ap2a1	IDA		Mouse	PMID:11879655
Cellular Component	GO:0032991	protein-containing complex	Ap2a1	IDA		Rat	PMID:11423532|RGD:1579732
Biological Process	GO:0072583	clathrin-dependent endocytosis	AP2A1	IMP		Human	PMID:22262466
Biological Process	GO:0072583	clathrin-dependent endocytosis	AP2A1	IDA		Human	PMID:23676497
Biological Process	GO:0072583	clathrin-dependent endocytosis	Ap2a1	IDA		Mouse	MGI:MGI:5514106|PMID:23676497
Biological Process	GO:0009950	dorsal/ventral axis specification	ap2a1	IMP	ZFIN:ZDB-MRPHLNO-120529-4	Zfish	PMID:22484487
Biological Process	GO:0009953	dorsal/ventral pattern formation	ap2a1	IMP	ZFIN:ZDB-MRPHLNO-120529-4	Zfish	PMID:22484487
Biological Process	GO:0060218	hematopoietic stem cell differentiation	ap2a1	IMP	ZFIN:ZDB-MRPHLNO-170127-2	Zfish	PMID:27797851
Biological Process	GO:1900126	negative regulation of hyaluronan biosynthetic process	AP2A1	IMP		Human	PMID:23509262
Biological Process	GO:1900126	negative regulation of hyaluronan biosynthetic process	AP2A1	IDA		Human	PMID:24251095
Biological Process	GO:0010976	positive regulation of neuron projection development	Ap2a1	IMP		Rat	PMID:11717353|RGD:13452389
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	Ap2a1	IMP		Rat	PMID:11717353|RGD:13452389

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern