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Ap2a1
Gene Detail
Symbol

Name
ID
Ap2a1
adaptor-related protein complex 2, alpha 1 subunit
MGI:101921
Synonyms
Adtaa
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.01 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:44900373-44929496 bp, - strand
From VEGA annotation of GRCm38

  29124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68997  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AP2A1
Protein SuperFamily: adaptor protein complex AP-2, alpha subunit
Gene Tree: Ap2a1

Human
homologs
AP2A1, adaptor-related protein complex 2, alpha 1 subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 160
neXtProt AC: NX_O95782

Human Synonyms: ADTAA, AP2-ALPHA, CLAPA1

Human Chr (Location): 19q13.33; chr19:49766923-49807112 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(2) Gene trapped(9) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ap2a1 interacts with 163 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process endocytosis, intracellular protein transport, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function protein binding, protein complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (56)    Tissues (7)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
Western blot 1
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ap2a1 ; ZFIN ap2a1    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035384 (Evidence)
Ensembl Gene Model ENSMUSG00000060279 (Evidence)
Entrez Gene 11771 (Evidence)
DFCI TC1772890, TC1623958, TC1695240, TC1617669, TC1576799
NIA Mouse Gene Index U028505, U371909
Consensus CDS Project CCDS52238.1, CCDS52239.1
International Mouse Phenotyping Consortium Status Ap2a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035384 VEGA Gene Model | MGI Sequence Detail 29124 C57BL/6J ±  kb
transcript OTTMUST00000090470 VEGA | MGI Sequence Detail 3449 Not Applicable 
polypeptide OTTMUSP00000049648 VEGA | MGI Sequence Detail 977 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(8) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017104 Adaptor protein complex AP-2, alpha subunit
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
InterPro IPR013038 Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
InterPro IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
InterPro IPR015873 Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
InterPro IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
InterPro IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology PR:000004099 AP-2 complex subunit alpha-1
References
(Earliest) J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
(Latest) J:204152 Onishi K, et al., Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci. 2013 Dec 4;33(49):19071-85
All references(45)
Other
accession IDs
MGD-MRK-18750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory