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Ap2a1 Gene Detail
Summary
  • Symbol
    Ap2a1
  • Name
    adaptor-related protein complex 2, alpha 1 subunit
  • Synonyms
    Adtaa
  • Feature Type
    protein coding gene
  • IDs
    MGI:101921
    NCBI Gene: 11771
Location & Maps
more
  • Sequence Map
    Chr7:44900373-44929496 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      29124 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.01 cM, cytoband B2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    AP2A1, adaptor related protein complex 2 alpha 1 subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AP2A1, adaptor related protein complex 2 alpha 1 subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADTAA, AP2-ALPHA, CLAPA1
  • Links
    NCBI Gene ID: 160
    neXtProt AC: NX_O95782

  • Chr Location
    19q13.33; chr19:49766923-49807112 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    2
  • Gene trapped
    9
  • Targeted
    2
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    56
  • Tissues
    7
  • cDNA Data
    9
  • Literature Summary
    8
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035384 VEGA Gene Model | MGI Sequence Detail 29124 C57BL/6J ±  kb
transcript OTTMUST00000090470 VEGA | MGI Sequence Detail 3449 Not Applicable  
polypeptide OTTMUSP00000049648 VEGA | MGI Sequence Detail 977 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    217 from dbSNP Build 142
  • PCR
    1
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004099 AP-2 complex subunit alpha-1
  • InterPro Domains
    IPR017104 Adaptor protein complex AP-2, alpha subunit
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
    IPR013038 Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
    IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
    IPR015873 Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
    IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
    IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
    IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18750
References
more
  • Summaries
    All 44
    Developmental Gene Expression 8
    Gene Ontology 11
    Phenotypes 6
  • Earliest
    J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
  • Latest
    J:221584 Quesnel-Vallieres M, et al., Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. Genes Dev. 2015 Apr 1;29(7):746-59
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory