Ap2a1
Gene Detail

Symbol

Name
ID

Ap2a1
adaptor-related protein complex 2, alpha 1 subunit
MGI:101921

Synonyms

Adtaa

Feature Type

protein coding gene

Genetic Map

Chromosome 7
29.01 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:44900373-44929496 bp, - strand From VEGA annotation of GRCm38   29124 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:68997  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adaptor protein complex AP-2, alpha subunit
Gene Tree: Ap2a1

Human
homologs

Human Homolog		AP2A1, adaptor-related protein complex 2, alpha 1 subunit
NCBI Gene ID		160
neXtProt AC		NX_O95782
Human Synonyms		ADTAA, AP2-ALPHA, CLAPA1
Human Chr (Location)		19q13.33; chr19:49766923-49807112 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(13) : Chemically induced (ENU)(2) Gene trapped(9) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Ap2a1 interacts with 164 markers (Mir15a, Mir15b, Mir16-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (24 annotations)

Process	endocytosis, intracellular protein transport, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	protein binding, protein complex binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (55)    Tissues (6)    Images (23)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	55

cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000035384 (Evidence)
Ensembl Gene Model	ENSMUSG00000060279 (Evidence)
Entrez Gene	11771 (Evidence)
DFCI	TC1695240, TC1576799, TC1623958, TC1617669, TC1772890
NIA Mouse Gene Index	U028505, U371909
Consensus CDS Project	CCDS52238.1, CCDS52239.1
International Mouse Knockout Project Status	Ap2a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035384	VEGA Gene Model | MGI Sequence Detail	29124	C57BL/6J
transcript	OTTMUST00000090470	VEGA | MGI Sequence Detail	3449	Not Applicable
polypeptide	OTTMUSP00000049648	VEGA | MGI Sequence Detail	977	Not Applicable

All sequences(68) RefSeq(8) UniProt(4)

Polymorphisms

PCR(1) : SNPs within 2kb(217 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017104	Adaptor protein complex AP-2, alpha subunit
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR003164	Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
InterPro	IPR013038	Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
InterPro	IPR008152	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
InterPro	IPR015873	Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
InterPro	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro	IPR009028	Coatomer/calthrin adaptor appendage, C-terminal subdomain
InterPro	IPR013041	Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology	PR:000004099	AP-2 complex subunit alpha-1

References

(Earliest) J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
(Latest) J:204152 Onishi K, et al., Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci. 2013 Dec 4;33(49):19071-85
All references(47)

Other
accession IDs

MGD-MRK-18750