Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AMELX,AMELY
  • Mouse genes Amelx
  • Rat genes Amelx
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Amelx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Amelx	IDA		Mouse	MGI:MGI:5882882|PMID:19086270
Molecular Function	GO:0008083	growth factor activity	Amelx	IMP		Mouse	MGI:MGI:3828399|PMID:16674693
Molecular Function	GO:0046848	hydroxyapatite binding	Amelx	IDA		Mouse	MGI:MGI:3828411|PMID:11852235
Molecular Function	GO:0042802	identical protein binding	Amelx	IPI	UniProtKB:P63277	Mouse	MGI:MGI:5882880|PMID:20304108
Molecular Function	GO:0042802	identical protein binding	Amelx	IPI	UniProtKB:P63277	Mouse	MGI:MGI:3828411|PMID:11852235
Molecular Function	GO:0042802	identical protein binding	Amelx	IPI	UniProtKB:P63277	Mouse	MGI:MGI:4366712|PMID:9041053
Molecular Function	GO:0042802	identical protein binding	Amelx	IDA		Mouse	PMID:23896516
Molecular Function	GO:0042802	identical protein binding	Amelx	IDA		Rat	PMID:16674699|RGD:1599097
Molecular Function	GO:0005515	protein binding	AMELX	IPI	UniProtKB:O60882	Human	PMID:18434575
Molecular Function	GO:0005515	protein binding	Amelx	IPI	UniProtKB:P11438	Mouse	MGI:MGI:3828400|PMID:16674683
Molecular Function	GO:0005515	protein binding	Amelx	IPI	UniProtKB:Q922U2	Mouse	MGI:MGI:2662799|PMID:12657653
Molecular Function	GO:0005515	protein binding	Amelx	IPI	PR:Q9Z1R2	Mouse	PMID:11063033
Molecular Function	GO:0042803	protein homodimerization activity	Amelx	IDA		Mouse	MGI:MGI:5882882|PMID:19086270
Molecular Function	GO:0031402	sodium ion binding	Amelx	IDA		Mouse	MGI:MGI:5882880|PMID:20304108
Molecular Function	GO:0031402	sodium ion binding	Amelx	IDA		Mouse	MGI:MGI:5882882|PMID:19086270
Molecular Function	GO:0030345	structural constituent of tooth enamel	AMELX	IMP		Human	PMID:1483698
Molecular Function	GO:0030345	structural constituent of tooth enamel	AMELX	IDA		Human	PMID:1734713
Molecular Function	GO:0030345	structural constituent of tooth enamel	AMELX	IDA		Human	PMID:2509010
Molecular Function	GO:0030345	structural constituent of tooth enamel	AMELY	IDA		Human	PMID:1734713
Molecular Function	GO:0030345	structural constituent of tooth enamel	Amelx	IDA		Rat	PMID:16674699|RGD:1599097
Cellular Component	GO:0005604	basement membrane	Amelx	IDA		Mouse	PMID:18757743
Cellular Component	GO:0009986	cell surface	Amelx	IMP		Mouse	MGI:MGI:3828400|PMID:16674683
Cellular Component	GO:0062023	collagen-containing extracellular matrix	AMELX	IDA		Human	PMID:2509010
Cellular Component	GO:0005737	cytoplasm	Amelx	IDA		Rat	PMID:12667550|RGD:1599089
Cellular Component	GO:0030139	endocytic vesicle	Amelx	IDA		Rat	PMID:10550615|RGD:1599096
Cellular Component	GO:0031012	extracellular matrix	Amelx	IDA		Rat	PMID:12667550|RGD:1599089
Cellular Component	GO:0005794	Golgi apparatus	Amelx	IDA		Rat	PMID:12667550|RGD:1599089
Cellular Component	GO:0032991	protein-containing complex	Amelx	IDA		Mouse	MGI:MGI:5882882|PMID:19086270
Cellular Component	GO:0099080	supramolecular complex	Amelx	IDA		Mouse	MGI:MGI:5882880|PMID:20304108
Biological Process	GO:0097186	amelogenesis	Amelx	IDA		Mouse	MGI:MGI:6716964|PMID:26403673
Biological Process	GO:0007155	cell adhesion	Amelx	IMP		Mouse	MGI:MGI:3828399|PMID:16674693
Biological Process	GO:0070166	enamel mineralization	AMELX	IMP		Human	PMID:1916828
Biological Process	GO:0070166	enamel mineralization	Amelx	IDA		Mouse	MGI:MGI:6716964|PMID:26403673
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Amelx	IEP		Mouse	MGI:MGI:3828400|PMID:16674683
Biological Process	GO:0042127	regulation of cell population proliferation	Amelx	IMP		Mouse	MGI:MGI:3828399|PMID:16674693
Biological Process	GO:0051592	response to calcium ion	Amelx	IEP		Rat	PMID:15721149|RGD:1599092
Biological Process	GO:0007584	response to nutrient	Amelx	IEP		Rat	PMID:12667550|RGD:1599089
Biological Process	GO:0009410	response to xenobiotic stimulus	Amelx	IEP		Rat	PMID:16461365|RGD:1599091
Biological Process	GO:0034505	tooth mineralization	AMELX	IMP		Human	PMID:1483698
Biological Process	GO:0034505	tooth mineralization	Amelx	IMP		Mouse	MGI:MGI:2149207|PMID:11406633

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern