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Amelx
Gene Detail
 Symbol
Name
ID
Amelx
amelogenin, X-linked
MGI:88005
Synonyms Amel, Amg, M100888, Rgsc888
Feature Type protein coding gene
Genetic Map
Chromosome X
78.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(47)
Sequence Map
ChrX:169176114-169187200 bp, - strand
From VEGA annotation of GRCm38

  11087 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47996  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 western clawed frog

Protein SuperFamily: amelogenin
Gene Tree: Amelx

Human
homologs
Human Homolog AMELY, amelogenin, Y-linked
NCBI Gene ID 266
neXtProt AC  NX_Q99218
Human Synonyms  AMGL, AMGY
Human Chr (Location)  Yp11.2; chrY:6865918-6874027 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutation of this gene results in brittle teeth and reduced enamel thickness.
 
Human Diseases Modeled Using Mouse Amelx (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(5)
Interactions
Amelx interacts with 27 markers (Mir22, Mir32, Mir124a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process biomineral tissue development, cell adhesion, ...
Component basement membrane, cell surface, ...
Function growth factor activity, hydroxyapatite binding, ...
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (50)    Tissues (26)    Images (7)
Theiler Stages: 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 4
Northern blot 5
RT-PCR 38
cDNA source data(50)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) Genomic(17) cDNA(51) Primer pair(8) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000019595 (Evidence)
Ensembl Gene ModelENSMUSG00000031354 (Evidence)
Entrez Gene11704 (Evidence)
UniGene391342
DFCITC1585078, TC1592975, TC1593326, TC1660874
DoTSDT.101408653, DT.87068423, DT.87068424
NIA Mouse Gene IndexU039885
Consensus CDS ProjectCCDS41213.1, CCDS41214.1
International Mouse Knockout Project StatusAmelx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019595 VEGA Gene Model | MGI Sequence Detail 11087 C57BL/6J ±  kb
transcript OTTMUST00000046811 VEGA | MGI Sequence Detail 802 Not Applicable 
polypeptide OTTMUSP00000021171 VEGA | MGI Sequence Detail 219 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(12) UniProt(4)
Polymorphisms All PCR and RFLP(10) : PCR(1) RFLP(9) SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004116 Amelogenin
Protein Ontology PR:000003988 amelogenin, X isoform
References (Earliest) J:20261 Snead ML, et al., DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein. Biochem Biophys Res Commun. 1985 Jun 28;129(3):812-8
(Latest) J:203117 Li X, et al., A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Hum Mol Genet. 2014 Jan 1;23(1):194-208
All references(150)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1295, MGD-MRK-1296, MGI:3807976

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory