Amelx
Gene Detail

Symbol Name ID

Amelx amelogenin X chromosome MGI:88005

Synonyms

Amel, Amg, M100888, Rgsc888

Feature Type

protein coding gene

Genetic Map

Chromosome X

78.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(47)

Sequence Map

ChrX:169176114-169187200 bp, - strand From VEGA annotation of GRCm38   11087 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: amelogenin
Gene Tree: Amelx

Human homologs

Human Homolog		AMELX, amelogenin, X-linked
NCBI Gene ID		265
neXtProt AC		NX_Q99217
Human Synonyms		AI1E, AIH1, ALGN, AMG, AMGL, AMGX
Human Chr (Location)		Xp22.31-p22.1; chrX:11311533-11318881 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AMELX

Alleles and phenotypes

All alleles(7) : Targeted(6) Chemically induced(1)
 

Homozygous mutation of this gene results in brittle teeth and reduced enamel thickness.

 
Human Diseases Modeled Using Mouse Amelx (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	biomineral tissue development, cell adhesion, ...
Component	basement membrane, cytoplasm, ...
Function	cell surface binding, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (41 records)
Data Summary: Results (48)    Tissues (21)    Images (5)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	2
Northern blot	5
RT-PCR	38

cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(76) Genomic(17) cDNA(50) Primer pair(8) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000019595 (Evidence)
Ensembl Gene Model	ENSMUSG00000031354 (Evidence)
Entrez Gene	11704 (Evidence)
UniGene	391342
DFCI	TC1585078, TC1592975, TC1593326, TC1660874
DoTS	DT.101408653, DT.87068423, DT.87068424
NIA Mouse Gene Index	U039885
Consensus CDS Project	CCDS41213.1, CCDS41214.1
International Mouse Knockout Project Status	Amelx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019595	VEGA Gene Model | MGI Sequence Detail	11087	C57BL/6J
transcript	OTTMUST00000046811	VEGA | MGI Sequence Detail	802	Not Applicable
polypeptide	OTTMUSP00000021171	VEGA | MGI Sequence Detail	219	Not Applicable

All sequences(50) RefSeq(4) UniProt(4)

Polymorphisms

All PCR and RFLP(10) : PCR(1) RFLP(9) SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004116	Amelogenin
Protein Ontology	PR:000003988	amelogenin, X isoform

References

(Earliest) J:20261 Snead ML, et al., DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein. Biochem Biophys Res Commun. 1985 Jun 28;129(3):812-8
(Latest) J:193857 Zhang Z, et al., The LIM homeodomain transcription factor LHX6: a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis. J Biol Chem. 2013 Jan 25;288(4):2485-500
All references(147)

Other accession IDs

MGD-MRK-1295, MGD-MRK-1296, MGI:3807976