Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALDH5A1
  • Mouse genes Aldh5a1
  • Rat genes Aldh5a1
  • Zfish genes aldh5a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aldh5a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031406	carboxylic acid binding	Aldh5a1	IPI	CHEBI:16265	Rat	PMID:12527414|RGD:1600514
Molecular Function	GO:0031406	carboxylic acid binding	Aldh5a1	IPI	CHEBI:16265	Rat	PMID:7262085|RGD:1600512
Molecular Function	GO:0042802	identical protein binding	ALDH5A1	IPI	UniProtKB:P51649	Human	PMID:16199352
Molecular Function	GO:0051287	NAD binding	Aldh5a1	IDA		Rat	PMID:12527414|RGD:1600514
Molecular Function	GO:0051287	NAD binding	Aldh5a1	IDA		Rat	PMID:12871571|RGD:1304407
Molecular Function	GO:0051287	NAD binding	Aldh5a1	IDA		Rat	PMID:7262085|RGD:1600512
Molecular Function	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	ALDH5A1	IDA		Human	PMID:16199352
Molecular Function	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	ALDH5A1	IDA		Human	PMID:9683595
Molecular Function	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	Aldh5a1	IDA		Rat	PMID:12527414|RGD:1600514
Molecular Function	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	Aldh5a1	IDA		Rat	PMID:12871571|RGD:1304407
Molecular Function	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	Aldh5a1	IDA		Rat	PMID:7262085|RGD:1600512
Molecular Function	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	Aldh5a1	IDA		Rat	PMID:7814412|RGD:632258
Cellular Component	GO:0005739	mitochondrion	ALDH5A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	ALDH5A1	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Aldh5a1	IDA		Mouse	MGI:MGI:2682130|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Aldh5a1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Aldh5a1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Aldh5a1	IDA		Rat	PMID:12527414|RGD:1600514
Cellular Component	GO:0005739	mitochondrion	Aldh5a1	IDA		Rat	PMID:12871571|RGD:1304407
Biological Process	GO:0007417	central nervous system development	ALDH5A1	IMP		Human	PMID:9683595
Biological Process	GO:0009450	gamma-aminobutyric acid catabolic process	ALDH5A1	IMP		Human	PMID:15037717
Biological Process	GO:0009450	gamma-aminobutyric acid catabolic process	ALDH5A1	IDA		Human	PMID:9683595
Biological Process	GO:0009450	gamma-aminobutyric acid catabolic process	Aldh5a1	IMP	MGI:MGI:2180159	Mouse	PMID:11544478
Biological Process	GO:0009450	gamma-aminobutyric acid catabolic process	Aldh5a1	IMP	MGI:MGI:2180159	Mouse	PMID:15262267
Biological Process	GO:0009448	gamma-aminobutyric acid metabolic process	Aldh5a1	IMP	MGI:MGI:2180159	Mouse	PMID:12067239
Biological Process	GO:0009448	gamma-aminobutyric acid metabolic process	Aldh5a1	IMP	MGI:MGI:2180159	Mouse	PMID:16647690
Biological Process	GO:0009448	gamma-aminobutyric acid metabolic process	Aldh5a1	IMP	MGI:MGI:2180159	Mouse	PMID:16504488
Biological Process	GO:0006536	glutamate metabolic process	Aldh5a1	IMP	MGI:MGI:2180159	Mouse	PMID:17854388
Biological Process	GO:0042135	neurotransmitter catabolic process	Aldh5a1	IMP	MGI:MGI:2180159	Mouse	PMID:15262267
Biological Process	GO:0009791	post-embryonic development	Aldh5a1	IMP	MGI:MGI:2180159	Mouse	PMID:12065715
Biological Process	GO:0006105	succinate metabolic process	Aldh5a1	IMP	MGI:MGI:2180159	Mouse	PMID:12065715
Biological Process	GO:0006105	succinate metabolic process	Aldh5a1	IDA		Rat	PMID:12527414|RGD:1600514
Biological Process	GO:0006105	succinate metabolic process	Aldh5a1	IDA		Rat	PMID:12871571|RGD:1304407
Biological Process	GO:0006105	succinate metabolic process	Aldh5a1	IDA		Rat	PMID:7262085|RGD:1600512
Biological Process	GO:0006105	succinate metabolic process	Aldh5a1	IDA		Rat	PMID:7814412|RGD:632258

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern