Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALAS2
  • Mouse genes Alas2
  • Rat genes Alas2
  • Zfish genes alas2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alas2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	ALAS2	IDA		Human	PMID:14643893
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	ALAS2	IMP		Human	PMID:21252495
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	ALAS2	IMP		Human	PMID:21309041
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	ALAS2	IMP		Human	PMID:21653323
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	ALAS2	IDA		Human	PMID:32499479
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	Alas2	IDA		Mouse	MGI:MGI:7260091|PMID:8268805
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	Alas2	IDA		Mouse	MGI:MGI:57091|PMID:3557128
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	Alas2	IMP		Mouse	PMID:7620186
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	Alas2	IDA		Rat	PMID:15181459|RGD:1581096
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	Alas2	IDA		Rat	PMID:8407861|RGD:632181
Molecular Function	GO:0120225	coenzyme A binding	Alas2	IDA		Rat	PMID:8407861|RGD:632181
Molecular Function	GO:0005515	protein binding	ALAS2	IPI	UniProtKB:Q9P2R7	Human	PMID:10727444
Molecular Function	GO:0005515	protein binding	ALAS2	IPI	UniProtKB:Q9P2R7	Human	PMID:14643893
Molecular Function	GO:0005515	protein binding	ALAS2	IPI	UniProtKB:P40337	Human	PMID:16234850
Molecular Function	GO:0005515	protein binding	ALAS2	IPI	UniProtKB:Q8N9N5	Human	PMID:25416956
Cellular Component	GO:0005743	mitochondrial inner membrane	ALAS2	IDA		Human	PMID:14643893
Cellular Component	GO:0005739	mitochondrion	ALAS2	IDA		Human	PMID:10727444
Cellular Component	GO:0005739	mitochondrion	ALAS2	IDA		Human	PMID:14643893
Cellular Component	GO:0005739	mitochondrion	Alas2	IDA		Mouse	MGI:MGI:57091|PMID:3557128
Cellular Component	GO:0005739	mitochondrion	Alas2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Alas2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Alas2	IDA		Rat	PMID:15496594|RGD:1581087
Biological Process	GO:0035162	embryonic hemopoiesis	alas2	IMP	ZFIN:ZDB-GENO-980202-1405	Zfish	PMID:9007251
Biological Process	GO:0035162	embryonic hemopoiesis	alas2	IMP	ZFIN:ZDB-GENO-980202-1405	Zfish	PMID:9806542
Biological Process	GO:0035162	embryonic hemopoiesis	alas2	IMP	ZFIN:ZDB-GENO-980202-1025	Zfish	PMID:9007251
Biological Process	GO:0035162	embryonic hemopoiesis	alas2	IMP	ZFIN:ZDB-GENO-980202-1025	Zfish	PMID:9806542
Biological Process	GO:0048821	erythrocyte development	alas2	IMP	ZFIN:ZDB-GENO-080326-4	Zfish	PMID:25957689
Biological Process	GO:0030218	erythrocyte differentiation	Alas2	IMP		Mouse	MGI:MGI:3694153|PMID:9446639
Biological Process	GO:0006783	heme biosynthetic process	Alas2	IMP		Mouse	MGI:MGI:3694153|PMID:9446639
Biological Process	GO:0006783	heme biosynthetic process	alas2	IMP	ZFIN:ZDB-GENO-980202-1405	Zfish	PMID:9806542
Biological Process	GO:0006783	heme biosynthetic process	alas2	IMP	ZFIN:ZDB-GENO-980202-1025	Zfish	PMID:9806542
Biological Process	GO:0042541	hemoglobin biosynthetic process	Alas2	IMP		Mouse	MGI:MGI:3694153|PMID:9446639
Biological Process	GO:0042541	hemoglobin biosynthetic process	alas2	IMP	ZFIN:ZDB-MRPHLNO-110131-2	Zfish	PMID:26821380
Biological Process	GO:0020027	hemoglobin metabolic process	alas2	IMP	ZFIN:ZDB-MRPHLNO-051205-1	Zfish	PMID:23615448
Biological Process	GO:0020027	hemoglobin metabolic process	alas2	IMP		Zfish	PMID:19412178
Biological Process	GO:0020027	hemoglobin metabolic process	alas2	IGI	ZFIN:ZDB-MRPHLNO-051205-1,ZFIN:ZDB-MRPHLNO-130731-2	Zfish	PMID:23615448
Biological Process	GO:0006879	intracellular iron ion homeostasis	Alas2	IMP	MGI:MGI:2180151	Mouse	PMID:10562540
Biological Process	GO:0007595	lactation	Alas2	IEP		Rat	PMID:18255020|RGD:4144779
Biological Process	GO:0097421	liver regeneration	Alas2	IEP		Rat	PMID:6895999|RGD:11035238
Biological Process	GO:0060135	maternal process involved in female pregnancy	Alas2	IEP		Rat	PMID:18255020|RGD:4144779
Biological Process	GO:1901423	response to benzene	Alas2	IEP		Rat	PMID:6895089|RGD:11035239
Biological Process	GO:0032025	response to cobalt ion	Alas2	IEP		Rat	PMID:2781150|RGD:11035236
Biological Process	GO:0070542	response to fatty acid	Alas2	IEP		Rat	PMID:21737922|RGD:11035225
Biological Process	GO:0001666	response to hypoxia	ALAS2	IDA		Human	PMID:16234850
Biological Process	GO:0001666	response to hypoxia	Alas2	IEP		Rat	PMID:17095594|RGD:1599040
Biological Process	GO:0010288	response to lead ion	Alas2	IEP		Rat	PMID:16597373|RGD:1599014
Biological Process	GO:0009410	response to xenobiotic stimulus	Alas2	IEP		Rat	PMID:16005536|RGD:4144195
Biological Process	GO:0009410	response to xenobiotic stimulus	Alas2	IEP		Rat	PMID:21296123|RGD:10449049

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern