Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADH4
  • Mouse genes Adh4
  • Rat genes Adh4
  • Zfish genes adh5l,adh8a,adh8b,zgc:77938
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adh4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	ADH4	IDA		Human	PMID:16787387
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	ADH4	IDA		Human	PMID:3466164
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	Adh4	IDA		Mouse	PMID:518534
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	Adh4	IDA		Rat	PMID:2774584|RGD:1358222
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	adh8b	IDA		Zfish	PMID:15231826
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	adh8a	IDA		Zfish	PMID:15231826
Molecular Function	GO:0004024	alcohol dehydrogenase activity, zinc-dependent	ADH4	IDA		Human	PMID:10407146
Molecular Function	GO:0004024	alcohol dehydrogenase activity, zinc-dependent	Adh4	IDA		Mouse	PMID:10514444
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Adh4	IDA		Mouse	PMID:10514444
Molecular Function	GO:0005503	all-trans retinal binding	ADH4	IDA		Human	PMID:15369820
Molecular Function	GO:0019115	benzaldehyde dehydrogenase [NAD(P)+] activity	ADH4	IDA		Human	PMID:3466164
Molecular Function	GO:0035276	ethanol binding	Adh4	IDA		Rat	PMID:2774584|RGD:1358222
Molecular Function	GO:0018467	formaldehyde dehydrogenase activity	adh8b	IDA		Zfish	PMID:15231826
Molecular Function	GO:0051287	NAD binding	ADH4	IDA		Human	PMID:10407146
Molecular Function	GO:0051287	NAD binding	Adh4	IDA		Rat	PMID:2774584|RGD:1358222
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	ADH4	IDA		Human	PMID:10514444
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	ADH4	IDA		Human	PMID:15369820
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	ADH4	IDA		Human	PMID:16787387
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	ADH4	IDA		Human	PMID:17279314
Molecular Function	GO:0003960	NADPH:quinone reductase activity	Adh4	IDA		Mouse	PMID:10514444
Molecular Function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	ADH4	IDA		Human	PMID:3466164
Molecular Function	GO:0005515	protein binding	ADH4	IPI	UniProtKB:Q86WT6-2	Human	PMID:32296183
Molecular Function	GO:0019841	retinol binding	ADH4	IDA		Human	PMID:10407146
Molecular Function	GO:0008270	zinc ion binding	ADH4	IDA		Human	PMID:10407146
Cellular Component	GO:0005829	cytosol	ADH4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ADH4	IDA		Human	GO_REF:0000052
Biological Process	GO:0007568	aging	Adh4	IEP		Rat	PMID:18207224|RGD:5129089
Biological Process	GO:0046164	alcohol catabolic process	Adh4	IDA		Mouse	PMID:10514444
Biological Process	GO:0006066	alcohol metabolic process	ADH4	IDA		Human	PMID:3466164
Biological Process	GO:0006066	alcohol metabolic process	adh8b	IDA		Zfish	PMID:15231826
Biological Process	GO:0006066	alcohol metabolic process	adh8a	IDA		Zfish	PMID:15231826
Biological Process	GO:0006081	cellular aldehyde metabolic process	ADH4	IDA		Human	PMID:3466164
Biological Process	GO:0006081	cellular aldehyde metabolic process	Adh4	IDA		Mouse	PMID:10514444
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	adh8a	IDA		Zfish	PMID:18618001
Biological Process	GO:0006067	ethanol metabolic process	Adh4	IDA		Mouse	PMID:518534
Biological Process	GO:0006067	ethanol metabolic process	adh8a	IDA		Zfish	PMID:15231826
Biological Process	GO:0006069	ethanol oxidation	ADH4	IDA		Human	PMID:16787387
Biological Process	GO:0006069	ethanol oxidation	Adh4	IDA		Rat	PMID:2774584|RGD:1358222
Biological Process	GO:0010430	fatty acid omega-oxidation	ADH4	IDA		Human	PMID:16081420
Biological Process	GO:0010430	fatty acid omega-oxidation	Adh4	IDA		Mouse	MGI:MGI:6355486|PMID:16081420
Biological Process	GO:0046292	formaldehyde metabolic process	adh8b	IDA		Zfish	PMID:15231826
Biological Process	GO:0006070	octanol metabolic process	adh8b	IDA		Zfish	PMID:15231826
Biological Process	GO:0042698	ovulation cycle	Adh4	IEP		Rat	PMID:11095078|RGD:2316105
Biological Process	GO:1901661	quinone metabolic process	Adh4	IDA		Mouse	PMID:10514444
Biological Process	GO:0001523	retinoid metabolic process	ADH4	IDA		Human	PMID:15369820
Biological Process	GO:0042572	retinol metabolic process	ADH4	IDA		Human	PMID:16787387
Biological Process	GO:0042572	retinol metabolic process	ADH4	IDA		Human	PMID:17279314

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern