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Adh4
Gene Detail
Symbol

Name
ID
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
MGI:1349472
Synonyms
Adh2, mouse class II type ADH
Feature Type
protein coding gene
Genetic Map
Chromosome 3
64.24 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:138415466-138430892 bp, + strand
From VEGA annotation of GRCm38

  15427 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20162  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: alcohol dehydrogenase
Gene Tree: Adh4

Human
homologs
Human Homolog ADH4, alcohol dehydrogenase 4 (class II), pi polypeptide
NCBI Gene ID 127
neXtProt AC  NX_P08319
Human Synonyms  ADH-2, HEL-S-4
Human Chr (Location)  4q22; chr4:99123681-99144298 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Adh4 interacts with 50 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (192)    Tissues (98)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 188
RT-PCR 4
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(11) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030507 (Evidence)
Ensembl Gene ModelENSMUSG00000037797 (Evidence)
Entrez Gene26876 (Evidence)
UniGene158750
DFCITC1588898
DoTSDT.91335604, DT.482717
NIA Mouse Gene IndexU003911
EC1.1.1.1
PDB1E3L, 1E3I, 1E3E
Consensus CDS ProjectCCDS38653.1
International Mouse Knockout Project StatusAdh4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030507 VEGA Gene Model | MGI Sequence Detail 15427 C57BL/6J ±  kb
transcript OTTMUST00000075538 VEGA | MGI Sequence Detail 1314 Not Applicable 
polypeptide OTTMUSP00000039621 VEGA | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(89 from dbSNP Build 137)    SNPs within 2kb including multiple locations(95)
Protein-related
information
ResourceIDDescription
InterPro IPR013149 Alcohol dehydrogenase, C-terminal
InterPro IPR013154 Alcohol dehydrogenase GroES-like
InterPro IPR002085 Alcohol dehydrogenase superfamily, zinc-type
InterPro IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
InterPro IPR011032 GroES-like
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000003770 alcohol dehydrogenase 4
References
(Earliest) J:6249 Holmes RS, Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3. Biochem Genet. 1979 Jun;17(5-6):461-72
(Latest) J:180672 Anvret A, et al., Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease. Behav Brain Res. 2012 Feb 1;227(1):252-7
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory