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Adh4 Gene Detail
Summary
  • Symbol
    Adh4
  • Name
    alcohol dehydrogenase 4 (class II), pi polypeptide
  • Synonyms
    Adh2, mouse class II type ADH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349472
    NCBI Gene: 26876
  • Gene Overview
    MyGene.info: ADH4
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:138415497-138430892 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 64.24 cM, cytoband H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349472
protein coding gene Chr3:138415466-138430892 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027930
protein coding gene Chr3:141468946-141484358 (+)
A/J MGP_AJ_G0027887
protein coding gene Chr3:136456516-136472783 (+)
AKR/J MGP_AKRJ_G0027853
protein coding gene Chr3:140082932-140096874 (+)
BALB/cJ MGP_BALBcJ_G0027899
protein coding gene Chr3:136267480-136284812 (+)
C3H/HeJ MGP_C3HHeJ_G0027629
protein coding gene Chr3:140412999-140439584 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028343
protein coding gene Chr3:146341331-146360648 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025681
protein coding gene Chr3:131875106-131888640 (+)
CAST/EiJ MGP_CASTEiJ_G0027085
protein coding gene Chr3:140191870-140210856 (+)
CBA/J MGP_CBAJ_G0027606
protein coding gene Chr3:151323184-151348068 (+)
DBA/2J MGP_DBA2J_G0027745
protein coding gene Chr3:135574040-135599869 (+)
FVB/NJ MGP_FVBNJ_G0027712
protein coding gene Chr3:133041531-133056751 (+)
LP/J MGP_LPJ_G0027855
protein coding gene Chr3:142852955-142872260 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027744
protein coding gene Chr3:159435561-159455683 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028401
protein coding gene Chr3:139635141-139650683 (+)
PWK/PhJ MGP_PWKPhJ_G0026809
protein coding gene Chr3:135343677-135365987 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026636
protein coding gene Chr3:137745441-137764710 (+)
WSB/EiJ MGP_WSBEiJ_G0027164
protein coding gene Chr3:140480411-140500330 (+)



Homology
more
  • Human Ortholog
    ADH4, alcohol dehydrogenase 4 (class II), pi polypeptide
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ADH4, alcohol dehydrogenase 4 (class II), pi polypeptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADH-2, HEL-S-4
  • Links
    NCBI Gene ID: 127
    neXtProt AC: NX_P08319
    UniProt: P08319

  • Chr Location
    4q23; chr4:99123657-99144330 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26876 NCBI Gene Model | MGI Sequence Detail 15396 C57BL/6J ±  kb
transcript NM_011996 RefSeq | MGI Sequence Detail 1312 C57BL/6  
polypeptide Q9QYY9 UniProt | EBI | MGI Sequence Detail 377 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 1
    cDNA 12
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:6249 Holmes RS, Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3. Biochem Genet. 1979 Jun;17(5-6):461-72
  • Latest
    J:180672 Anvret A, et al., Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease. Behav Brain Res. 2012 Feb 1;227(1):252-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory