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Adh4 Gene Detail
Summary
  • Symbol
    Adh4
  • Name
    alcohol dehydrogenase 4 (class II), pi polypeptide
  • Synonyms
    Adh2, mouse class II type ADH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349472
    NCBI Gene: 26876
  • Gene Overview
    MyGene.info: ADH4
Location & Maps
more
  • Sequence Map
    Chr3:138415466-138430892 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15427 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 64.24 cM, cytoband H2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADH4, alcohol dehydrogenase 4 (class II), pi polypeptide
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ADH4, alcohol dehydrogenase 4 (class II), pi polypeptide
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADH-2, HEL-S-4
  • Links
    NCBI Gene ID: 127
    neXtProt AC: NX_P08319

  • Chr Location
    4q22; chr4:99123681-99144314 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Adh4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030507 VEGA Gene Model | MGI Sequence Detail 15427 C57BL/6J ±  kb
transcript OTTMUST00000075538 VEGA | MGI Sequence Detail 1314 Not Applicable  
polypeptide OTTMUSP00000039621 VEGA | MGI Sequence Detail 377 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    86 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 11
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:6249 Holmes RS, Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3. Biochem Genet. 1979 Jun;17(5-6):461-72
  • Latest
    J:180672 Anvret A, et al., Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease. Behav Brain Res. 2012 Feb 1;227(1):252-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory