Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADAMTS12
  • Mouse genes Adamts12
  • Rat genes Adamts12
  • Zfish genes adamts12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adamts12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAMTS12	IDA		Human	PMID:16611630
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAMTS12	IDA		Human	PMID:17895370
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAMTS12	IDA		Human	PMID:18485748
Molecular Function	GO:0005515	protein binding	ADAMTS12	IPI	UniProtKB:P49747	Human	PMID:16611630
Molecular Function	GO:0005515	protein binding	ADAMTS12	IPI	UniProtKB:Q9R0G6	Human	PMID:16611630
Molecular Function	GO:0005515	protein binding	ADAMTS12	IPI	UniProtKB:P01023	Human	PMID:18485748
Molecular Function	GO:0005515	protein binding	ADAMTS12	IPI	UniProtKB:P49747	Human	PMID:18485748
Molecular Function	GO:0005515	protein binding	ADAMTS12	IPI	UniProtKB:B4DJ51	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ADAMTS12	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ADAMTS12	IPI	UniProtKB:P60660	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ADAMTS12	IPI	UniProtKB:P60660	Human	PMID:31515488
Biological Process	GO:0016477	cell migration	ADAMTS12	IMP		Human	PMID:21494557
Biological Process	GO:0007160	cell-matrix adhesion	ADAMTS12	IMP		Human	PMID:21494557
Biological Process	GO:0071773	cellular response to BMP stimulus	ADAMTS12	IDA		Human	PMID:22247065
Biological Process	GO:0071347	cellular response to interleukin-1	ADAMTS12	IMP		Human	PMID:18485748
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ADAMTS12	IMP		Human	PMID:18485748
Biological Process	GO:0002062	chondrocyte differentiation	Adamts12	IGI	MGI:MGI:1347346	Mouse	PMID:29618652
Biological Process	GO:0030199	collagen fibril organization	Adamts12	IGI	MGI:MGI:1347346	Mouse	PMID:29618652
Biological Process	GO:0030199	collagen fibril organization	Adamts12	IGI	MGI:MGI:2146046	Mouse	PMID:29618652
Biological Process	GO:2001113	negative regulation of cellular response to hepatocyte growth factor stimulus	ADAMTS12	IDA		Human	PMID:17895370
Biological Process	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	ADAMTS12	IDA		Human	PMID:17895370
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	ADAMTS12	IDA		Human	PMID:22247065
Biological Process	GO:1902203	negative regulation of hepatocyte growth factor receptor signaling pathway	ADAMTS12	IDA		Human	PMID:17895370
Biological Process	GO:0001503	ossification	Adamts12	IGI	MGI:MGI:1347346	Mouse	PMID:29618652
Biological Process	GO:0043931	ossification involved in bone maturation	Adamts12	IGI	MGI:MGI:1347346	Mouse	PMID:29618652
Biological Process	GO:0043931	ossification involved in bone maturation	Adamts12	IGI	MGI:MGI:2146046	Mouse	PMID:29618652
Biological Process	GO:0030167	proteoglycan catabolic process	ADAMTS12	IDA		Human	PMID:17895370
Biological Process	GO:0006029	proteoglycan metabolic process	Adamts12	IGI	MGI:MGI:1347346	Mouse	PMID:29618652
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ADAMTS12	IDA		Human	PMID:16611630
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ADAMTS12	IMP		Human	PMID:18485748
Biological Process	GO:1901509	regulation of endothelial tube morphogenesis	ADAMTS12	IDA		Human	PMID:17895370
Biological Process	GO:0050727	regulation of inflammatory response	ADAMTS12	IDA		Human	PMID:23019333

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern