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Adamts12
Gene Detail
Symbol

Name
ID
Adamts12
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
MGI:2146046
Feature Type
protein coding gene
Genetic Map
Chromosome 15
5.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:11064790-11346867 bp, + strand
From NCBI annotation of GRCm38

  282078 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12808  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADAMTS12
Gene Tree: Adamts12

Human
homologs
ADAMTS12, ADAM metallopeptidase with thrombospondin type 1 motif, 12
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 81792
neXtProt AC: NX_P58397

Human Synonyms: PRO4389

Human Chr (Location): 5q35; chr5:33523535-33892194 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased tumor vascularization, tumor invasion, and angiogenesis.
 
Interactions
Adamts12 interacts with 228 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell-matrix adhesion, cell migration, ...
Component extracellular matrix, extracellular region, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (166)    Tissues (17)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 165
RT-PCR 1
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adamts12    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000047497 (Evidence)
Entrez Gene 239337 (Evidence)
DFCI TC1589671, TC1650038, TC1597289
DoTS DT.482237, DT.101142477, DT.94168331, DT.91393308
NIA Mouse Gene Index U095627
EC 3.4.24.-
Consensus CDS Project CCDS27384.1
International Mouse Phenotyping Consortium Status Adamts12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 239337 NCBI Gene Model | MGI Sequence Detail 282078 C57BL/6J ±  kb
transcript NM_175501 RefSeq | MGI Sequence Detail 6234 C57BL/6 
polypeptide Q811B3 UniProt | EBI | MGI Sequence Detail 1600 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(2167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR002870 Peptidase M12B, propeptide
InterPro IPR010909 PLAC
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000029296 a disintegrin and metalloproteinase with thrombospondin motifs 12
Graphical View of Protein Domain Structure
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:192638 Moncada-Pazos A, et al., ADAMTS-12 metalloprotease is necessary for normal inflammatory response. J Biol Chem. 2012 Nov 16;287(47):39554-63
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory