Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Acvr2b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ACVR2B
- Mouse genes Acvr2b
- Rat genes Acvr2b
- Zfish genes acvr2ba
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acvr2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048185	activin binding	Acvr2b	IDA		Mouse	PMID:15304227
Molecular Function	GO:0048185	activin binding	Acvr2b	IPI	UniProtKB:P08476	Mouse	PMID:1310075
Molecular Function	GO:0048185	activin binding	Acvr2b	IPI	UniProtKB:P08476	Mouse	PMID:1326537
Molecular Function	GO:0048185	activin binding	Acvr2b	IDA		Rat	PMID:12385827\|RGD:1579945
Molecular Function	GO:0019838	growth factor binding	ACVR2B	IPI	UniProtKB:O14793	Human	PMID:14517293
Molecular Function	GO:0019838	growth factor binding	Acvr2b	IMP	UniProtKB:O95390	Mouse	PMID:12414726
Molecular Function	GO:0019838	growth factor binding	Acvr2b	IPI	PR:O08689	Mouse	PMID:11459935
Molecular Function	GO:0034711	inhibin binding	Acvr2b	IDA		Rat	PMID:12385827\|RGD:1579945
Molecular Function	GO:0005515	protein binding	ACVR2B	IPI	UniProtKB:Q8N6C5	Human	PMID:11266516
Molecular Function	GO:0005515	protein binding	ACVR2B	IPI	UniProtKB:Q8WUH2	Human	PMID:11278302
Molecular Function	GO:0005515	protein binding	ACVR2B	IPI	UniProtKB:O60749	Human	PMID:11279102
Molecular Function	GO:0005515	protein binding	ACVR2B	IPI	UniProtKB:Q13596	Human	PMID:11279102
Molecular Function	GO:0005515	protein binding	ACVR2B	IPI	UniProtKB:Q9UNH7	Human	PMID:11279102
Molecular Function	GO:0005515	protein binding	ACVR2B	IPI	UniProtKB:O14793	Human	PMID:23829672
Molecular Function	GO:0005515	protein binding	ACVR2B	IPI	UniProtKB:P36896	Human	PMID:8622651
Molecular Function	GO:0005515	protein binding	ACVR2B	IPI	UniProtKB:P17813	Human	PMID:9872992
Molecular Function	GO:0005515	protein binding	Acvr2b	IPI	UniProtKB:P36896	Mouse	MGI:MGI:5918418\|PMID:14966532
Molecular Function	GO:0005515	protein binding	Acvr2b	IPI	PR:Q9D6K5	Mouse	PMID:11882656
Molecular Function	GO:0005515	protein binding	Acvr2b	IPI	PR:Q922H7	Mouse	PMID:15239668
Molecular Function	GO:0005515	protein binding	Acvr2b	IPI	PR:Q9Z1W4	Mouse	PMID:16845371
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVR2B	EXP		Human	PMID:8622651
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVR2B	IMP		Human	PMID:8622651
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVR2B	EXP		Human	PMID:8721982
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Acvr2b	IDA		Mouse	PMID:1326537
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	Acvr2b	IDA		Mouse	PMID:1326537
Cellular Component	GO:0005737	cytoplasm	ACVR2B	IDA		Human	PMID:14738881
Cellular Component	GO:0032991	protein-containing complex	ACVR2B	IDA		Human	PMID:24019467
Cellular Component	GO:0043235	receptor complex	ACVR2B	IPI	UniProtKB:P17813	Human	PMID:9872992
Biological Process	GO:0032147	activation of protein kinase activity	Acvr2b	IDA		Mouse	PMID:16806156
Biological Process	GO:0032924	activin receptor signaling pathway	ACVR2B	IMP		Human	PMID:18326817
Biological Process	GO:0030325	adrenal gland development	Acvr2b	IEP		Rat	PMID:12844345\|RGD:728125
Biological Process	GO:0009952	anterior/posterior pattern specification	ACVR2B	IMP		Human	PMID:9916847
Biological Process	GO:0009952	anterior/posterior pattern specification	Acvr2b	IGI	MGI:MGI:102806	Mouse	PMID:10452853
Biological Process	GO:0009952	anterior/posterior pattern specification	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:16991118
Biological Process	GO:0009952	anterior/posterior pattern specification	Acvr2b	IGI	MGI:MGI:102806	Mouse	PMID:16991118
Biological Process	GO:0009952	anterior/posterior pattern specification	Acvr2b	IGI	MGI:MGI:98728	Mouse	PMID:16845371
Biological Process	GO:0009952	anterior/posterior pattern specification	Acvr2b	IGI	MGI:MGI:1095407	Mouse	PMID:15542835
Biological Process	GO:0009952	anterior/posterior pattern specification	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:16845371
Biological Process	GO:0009952	anterior/posterior pattern specification	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:9242489
Biological Process	GO:0060840	artery development	Acvr2b	IMP		Mouse	MGI:MGI:4436974\|PMID:19903896
Biological Process	GO:0001974	blood vessel remodeling	Acvr2b	IMP		Mouse	MGI:MGI:4436974\|PMID:19903896
Biological Process	GO:0030509	BMP signaling pathway	ACVR2B	IDA		Human	PMID:18436533
Biological Process	GO:0030509	BMP signaling pathway	ACVR2B	IMP		Human	PMID:19903896
Biological Process	GO:0051216	cartilage development	acvr2ba	IMP	ZFIN:ZDB-MRPHLNO-050811-2	Zfish	PMID:15977175
Biological Process	GO:0007368	determination of left/right symmetry	Acvr2b	IGI	MGI:MGI:102806	Mouse	PMID:16991118
Biological Process	GO:0007368	determination of left/right symmetry	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:9242489
Biological Process	GO:0048617	embryonic foregut morphogenesis	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:10921901
Biological Process	GO:0001702	gastrulation with mouth forming second	Acvr2b	IGI	MGI:MGI:102806	Mouse	PMID:10452853
Biological Process	GO:0007507	heart development	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:9242489
Biological Process	GO:0007507	heart development	Acvr2b	IGI	MGI:MGI:108051	Mouse	PMID:17849440
Biological Process	GO:0030902	hindbrain development	acvr2ba	IMP	ZFIN:ZDB-MRPHLNO-050811-2	Zfish	PMID:15977175
Biological Process	GO:0030073	insulin secretion	Acvr2b	IGI	MGI:MGI:108051	Mouse	PMID:17849440
Biological Process	GO:0001822	kidney development	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:16845371
Biological Process	GO:0001822	kidney development	Acvr2b	IGI	MGI:MGI:98728	Mouse	PMID:16845371
Biological Process	GO:0030324	lung development	Acvr2b	IGI	MGI:MGI:108051	Mouse	PMID:17849440
Biological Process	GO:0001946	lymphangiogenesis	Acvr2b	IMP		Mouse	MGI:MGI:4436974\|PMID:19903896
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	Acvr2b	IMP		Mouse	MGI:MGI:4436974\|PMID:19903896
Biological Process	GO:0007498	mesoderm development	Acvr2b	IGI	MGI:MGI:102806	Mouse	PMID:10452853
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Acvr2b	IMP		Mouse	MGI:MGI:5432851\|PMID:22586266
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ACVR2B	IGI	UniProtKB:Q6ZVN8	Human	PMID:18326817
Biological Process	GO:0001755	neural crest cell migration	acvr2ba	IMP	ZFIN:ZDB-MRPHLNO-050811-2	Zfish	PMID:15977175
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:16330774
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Acvr2b	IMP	MGI:MGI:2179547	Mouse	PMID:11714685
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:11714685
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Acvr2b	IGI	MGI:MGI:102806	Mouse	PMID:16330774
Biological Process	GO:0035265	organ growth	Acvr2b	IGI	MGI:MGI:108051	Mouse	PMID:17849440
Biological Process	GO:0031016	pancreas development	Acvr2b	IGI	MGI:MGI:108051	Mouse	PMID:17849440
Biological Process	GO:0007389	pattern specification process	Acvr2b	IGI	MGI:MGI:108051	Mouse	PMID:17849440
Biological Process	GO:0032927	positive regulation of activin receptor signaling pathway	ACVR2B	IDA		Human	PMID:8622651
Biological Process	GO:0030501	positive regulation of bone mineralization	ACVR2B	IMP		Human	PMID:18436533
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ACVR2B	IMP		Human	PMID:18436533
Biological Process	GO:0009791	post-embryonic development	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:17849440
Biological Process	GO:0009791	post-embryonic development	Acvr2b	IGI	MGI:MGI:108051	Mouse	PMID:17849440
Biological Process	GO:0006355	regulation of DNA-templated transcription	ACVR2B	IDA		Human	PMID:8622651
Biological Process	GO:0009966	regulation of signal transduction	Acvr2b	IDA		Mouse	PMID:17936261
Biological Process	GO:0014823	response to activity	Acvr2b	IEP		Rat	PMID:22332899\|RGD:151665479
Biological Process	GO:0009749	response to glucose	Acvr2b	IGI	MGI:MGI:108051	Mouse	PMID:17849440
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Acvr2b	IMP		Mouse	MGI:MGI:4436974\|PMID:19903896
Biological Process	GO:0060021	roof of mouth development	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:16845371
Biological Process	GO:0060021	roof of mouth development	Acvr2b	IGI	MGI:MGI:98728	Mouse	PMID:16845371
Biological Process	GO:0007165	signal transduction	ACVR2B	IDA		Human	PMID:8622651
Biological Process	GO:0001501	skeletal system development	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:16845371
Biological Process	GO:0001501	skeletal system development	Acvr2b	IGI	MGI:MGI:98728	Mouse	PMID:16845371
Biological Process	GO:0001501	skeletal system development	acvr2ba	IMP	ZFIN:ZDB-MRPHLNO-050811-2	Zfish	PMID:15977175
Biological Process	GO:0048705	skeletal system morphogenesis	Acvr2b	IMP	MGI:MGI:1857709	Mouse	PMID:16991118
Biological Process	GO:0048705	skeletal system morphogenesis	Acvr2b	IGI	MGI:MGI:98728	Mouse	PMID:16845371
Biological Process	GO:0060841	venous blood vessel development	Acvr2b	IMP		Mouse	MGI:MGI:4436974\|PMID:19903896

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.