Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACER1
  • Mouse genes Acer1
  • Rat genes Acer1
  • Zfish genes acer1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acer1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071633	dihydroceramidase activity	ACER1	IMP		Human	PMID:20207939
Molecular Function	GO:0071633	dihydroceramidase activity	ACER1	IDA		Human	PMID:20628055
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ACER1	IDA		Human	PMID:17713573
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Acer1	IDA		Mouse	MGI:MGI:6107252|PMID:29056331
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Acer1	IDA		Mouse	PMID:12783875
Molecular Function	GO:0005515	protein binding	ACER1	IPI	UniProtKB:Q00013	Human	PMID:32296183
Cellular Component	GO:0005783	endoplasmic reticulum	ACER1	IDA		Human	PMID:17713573
Cellular Component	GO:0005783	endoplasmic reticulum	Acer1	IDA		Mouse	PMID:12783875
Biological Process	GO:0030154	cell differentiation	ACER1	IMP		Human	PMID:17713573
Biological Process	GO:0071277	cellular response to calcium ion	ACER1	IDA		Human	PMID:17713573
Biological Process	GO:0046514	ceramide catabolic process	ACER1	IMP		Human	PMID:20207939
Biological Process	GO:0046514	ceramide catabolic process	Acer1	IMP		Mouse	MGI:MGI:5800647|PMID:27126290
Biological Process	GO:0046514	ceramide catabolic process	Acer1	IDA		Mouse	PMID:12783875
Biological Process	GO:0008544	epidermis development	ACER1	IEP		Human	PMID:16477081
Biological Process	GO:0030216	keratinocyte differentiation	ACER1	IEP		Human	PMID:16477081
Biological Process	GO:0019216	regulation of lipid metabolic process	Acer1	IDA		Mouse	PMID:12783875
Biological Process	GO:0010446	response to alkaline pH	ACER1	IDA		Human	PMID:17713573
Biological Process	GO:0048733	sebaceous gland development	Acer1	IMP		Mouse	MGI:MGI:5800647|PMID:27126290
Biological Process	GO:0030148	sphingolipid biosynthetic process	ACER1	IDA		Human	PMID:17713573
Biological Process	GO:0006665	sphingolipid metabolic process	Acer1	IDA		Mouse	PMID:12783875
Biological Process	GO:0046512	sphingosine biosynthetic process	ACER1	IDA		Human	PMID:17713573
Biological Process	GO:0046512	sphingosine biosynthetic process	ACER1	IMP		Human	PMID:20207939
Biological Process	GO:0046512	sphingosine biosynthetic process	ACER1	IDA		Human	PMID:20628055
Biological Process	GO:0046512	sphingosine biosynthetic process	Acer1	IMP		Mouse	MGI:MGI:5800647|PMID:27126290
Biological Process	GO:0046512	sphingosine biosynthetic process	Acer1	IMP		Mouse	MGI:MGI:6107252|PMID:29056331

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern