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Acer1 Gene Detail
Summary
  • Symbol
    Acer1
  • Name
    alkaline ceramidase 1
  • Synonyms
    2310024P18Rik, Asah3, Cer1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181962
    NCBI Gene: 171168
  • Gene Overview
    MyGene.info: ACER1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:56953490-56982126 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28637 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.59 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ACER1, alkaline ceramidase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACER1, alkaline ceramidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALKCDase1, ASAH3
  • Links
    NCBI Gene ID: 125981
    neXtProt AC: NX_Q8TDN7
    UniProt: Q8TDN7

  • Chr Location
    19p13.3; chr19:6306142-6360359 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 15853
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACER1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show increased ceramide levels, hair shaft abnormalities, cyclic alopecia, epidermal hyperplasia, sebaceous gland and infundibulum expansion, increased epidermal water loss, and hypermetabolism along with decreased body weight and adipose tissue depots during aging.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 171168 NCBI Gene Model | MGI Sequence Detail 28637 C57BL/6J ±  kb
    transcript NM_175731 RefSeq | MGI Sequence Detail 2429 C57BL/6  
    polypeptide Q8R4X1 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      129 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923689, MGI:2146910
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:252017 Lin CL, et al., Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. 2017 Nov 14;9(5):1488-1500

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory