Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACAT2
  • Mouse genes Acat3
  • Rat genes Acat2,Acat2l1
  • Zfish genes acat2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acat3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	ACAT2	IDA		Human	PMID:7911016
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	Acat2	IDA		Rat	PMID:10806397|RGD:2326086
Molecular Function	GO:0005515	protein binding	ACAT2	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	ACAT2	IPI	UniProtKB:Q8TBB1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACAT2	IPI	UniProtKB:P36508	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACAT2	IPI	UniProtKB:Q9NZC7-5	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	ACAT2	IDA		Human	PMID:7911016
Cellular Component	GO:0005829	cytosol	Acat2	IDA		Rat	PMID:10806397|RGD:2326086
Cellular Component	GO:0070062	extracellular exosome	ACAT2	HDA		Human	PMID:23533145
Cellular Component	GO:0005739	mitochondrion	Acat3	HDA		Mouse	PMID:18614015
Biological Process	GO:0038183	bile acid signaling pathway	Acat2	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0007420	brain development	Acat2	IEP		Rat	PMID:4721608|RGD:2326094
Biological Process	GO:0071398	cellular response to fatty acid	Acat2	IEP		Rat	PMID:11786296|RGD:1598704
Biological Process	GO:0031670	cellular response to nutrient	Acat2	IEP		Rat	PMID:12563020|RGD:1598705
Biological Process	GO:0046952	ketone body catabolic process	Acat2	IEP		Rat	PMID:5116556|RGD:2326095
Biological Process	GO:0001889	liver development	Acat2	IEP		Rat	PMID:5166591|RGD:2326169

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern