Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCB6
  • Mouse genes Abcb6
  • Rat genes Abcb6
  • Zfish genes abcb6a,abcb6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcb6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015439	ABC-type heme transporter activity	ABCB6	IMP		Human	PMID:17006453
Molecular Function	GO:0140359	ABC-type transporter activity	ABCB6	IMP		Human	PMID:23792964
Molecular Function	GO:0140359	ABC-type transporter activity	ABCB6	IDA		Human	PMID:27507172
Molecular Function	GO:0140359	ABC-type transporter activity	Abcb6	IMP		Mouse	MGI:MGI:5424330|PMID:22294697
Molecular Function	GO:0140359	ABC-type transporter activity	Abcb6	IDA		Mouse	MGI:MGI:5898211|PMID:27507172
Molecular Function	GO:0005524	ATP binding	ABCB6	IDA		Human	PMID:10837493
Molecular Function	GO:0005524	ATP binding	ABCB6	IDA		Human	PMID:27507172
Molecular Function	GO:0016887	ATP hydrolysis activity	ABCB6	IDA		Human	PMID:33007128
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCB6	IDA		Human	PMID:17661442
Molecular Function	GO:0020037	heme binding	ABCB6	IDA		Human	PMID:17006453
Molecular Function	GO:0020037	heme binding	ABCB6	IDA		Human	PMID:33007128
Molecular Function	GO:0046906	tetrapyrrole binding	ABCB6	IDA		Human	PMID:17006453
Molecular Function	GO:0046906	tetrapyrrole binding	ABCB6	IDA		Human	PMID:23792964
Cellular Component	GO:0005829	cytosol	ABCB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031901	early endosome membrane	Abcb6	IDA		Rat	PMID:18160489|RGD:42722002
Cellular Component	GO:0036020	endolysosome membrane	ABCB6	IDA		Human	PMID:25627919
Cellular Component	GO:0036020	endolysosome membrane	ABCB6	IDA		Human	PMID:31053883
Cellular Component	GO:0036020	endolysosome membrane	Abcb6	IDA		Rat	PMID:18160489|RGD:42722002
Cellular Component	GO:0005783	endoplasmic reticulum	ABCB6	IDA		Human	PMID:22226084
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ABCB6	IDA		Human	PMID:21199866
Cellular Component	GO:0005768	endosome	Abcb6	IDA		Mouse	MGI:MGI:5546319|PMID:23519333
Cellular Component	GO:0070062	extracellular exosome	ABCB6	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ABCB6	IDA		Human	PMID:22655043
Cellular Component	GO:0070062	extracellular exosome	Abcb6	IDA		Mouse	MGI:MGI:6232721|PMID:22655043
Cellular Component	GO:0005794	Golgi apparatus	ABCB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	ABCB6	IDA		Human	PMID:18279659
Cellular Component	GO:0005794	Golgi apparatus	ABCB6	IDA		Human	PMID:21199866
Cellular Component	GO:0005794	Golgi apparatus	ABCB6	IDA		Human	PMID:22226084
Cellular Component	GO:0031902	late endosome membrane	Abcb6	IDA		Rat	PMID:18160489|RGD:42722002
Cellular Component	GO:0005765	lysosomal membrane	ABCB6	IDA		Human	PMID:22655043
Cellular Component	GO:0005765	lysosomal membrane	ABCB6	IDA		Human	PMID:25627919
Cellular Component	GO:0005765	lysosomal membrane	ABCB6	IDA		Human	PMID:29940187
Cellular Component	GO:0005765	lysosomal membrane	ABCB6	IDA		Human	PMID:31053883
Cellular Component	GO:0005765	lysosomal membrane	Abcb6	IDA		Rat	PMID:18160489|RGD:42722002
Cellular Component	GO:0033162	melanosome membrane	ABCB6	IDA		Human	PMID:29940187
Cellular Component	GO:0005740	mitochondrial envelope	ABCB6	IDA		Human	PMID:10837493
Cellular Component	GO:0005741	mitochondrial outer membrane	ABCB6	IDA		Human	PMID:17006453
Cellular Component	GO:0005741	mitochondrial outer membrane	ABCB6	IDA		Human	PMID:17661442
Cellular Component	GO:0005739	mitochondrion	ABCB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	ABCB6	IDA		Human	PMID:10837493
Cellular Component	GO:0005739	mitochondrion	ABCB6	IMP		Human	PMID:23792964
Cellular Component	GO:0005739	mitochondrion	Abcb6	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Abcb6	IDA		Rat	PMID:10837493|RGD:1300326
Cellular Component	GO:0032585	multivesicular body membrane	ABCB6	IDA		Human	PMID:25627919
Cellular Component	GO:0005654	nucleoplasm	ABCB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ABCB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ABCB6	IDA		Human	PMID:17661442
Cellular Component	GO:0005886	plasma membrane	ABCB6	IDA		Human	PMID:22655043
Cellular Component	GO:0005886	plasma membrane	ABCB6	IDA		Human	PMID:25627919
Cellular Component	GO:0005886	plasma membrane	ABCB6	IDA		Human	PMID:27507172
Biological Process	GO:0007420	brain development	ABCB6	IMP		Human	PMID:22100072
Biological Process	GO:0098849	cellular detoxification of cadmium ion	ABCB6	IDA		Human	PMID:31053883
Biological Process	GO:0042168	heme metabolic process	ABCB6	IDA		Human	PMID:33007128
Biological Process	GO:0035351	heme transmembrane transport	ABCB6	IDA		Human	PMID:33007128
Biological Process	GO:0015886	heme transport	ABCB6	IMP		Human	PMID:17006453
Biological Process	GO:0015886	heme transport	ABCB6	IDA		Human	PMID:17661442
Biological Process	GO:0006878	intracellular copper ion homeostasis	Abcb6	IDA		Rat	PMID:18160489|RGD:42722002
Biological Process	GO:0061072	iris morphogenesis	abcb6a	IMP	ZFIN:ZDB-MRPHLNO-120216-6	Zfish	PMID:22226084
Biological Process	GO:0061072	iris morphogenesis	abcb6a	IMP	ZFIN:ZDB-MRPHLNO-120216-5	Zfish	PMID:22226084
Biological Process	GO:0097325	melanocyte proliferation	abcb6a	IMP	ZFIN:ZDB-MRPHLNO-140613-1,ZFIN:ZDB-MRPHLNO-140613-2	Zfish	PMID:24498303
Biological Process	GO:0097325	melanocyte proliferation	abcb6a	IMP	ZFIN:ZDB-MRPHLNO-140613-3,ZFIN:ZDB-MRPHLNO-140618-3	Zfish	PMID:24498303
Biological Process	GO:1903232	melanosome assembly	ABCB6	IDA		Human	PMID:29940187
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	ABCB6	IDA		Human	PMID:17006453
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	ABCB6	IDA		Human	PMID:27507172
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	ABCB6	IMP		Human	PMID:33007128
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Abcb6	IDA		Mouse	MGI:MGI:5898211|PMID:27507172
Biological Process	GO:0043588	skin development	ABCB6	IMP		Human	PMID:22100072
Biological Process	GO:0033013	tetrapyrrole metabolic process	ABCB6	IMP		Human	PMID:23792964

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern