Abcb6
Gene Detail

Symbol Name ID

Abcb6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 MGI:1921354

Synonyms

1200005B17Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

38.62 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:75171717-75180392 bp, - strand From VEGA annotation of GRCm38   8676 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Abcb6

Human homologs

Human Homolog		ABCB6, ATP-binding cassette, sub-family B (MDR/TAP), member 6
NCBI Gene ID		10058
neXtProt AC		NX_Q9NP58
Human Synonyms		ABC, ABC14, LAN, MCOPCB7, MTABC3, PRP, umat
Human Chr (Location)		2q36; chr2:220074488-220083712 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ABCB6

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a null mutation display partial lethality, impaired stress erythropoiesis, and absence of ATP-dependent transport of Coproporphyrin III in mitochondria.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	brain development, cadmium ion transmembrane transport, ...
Component	endoplasmic reticulum, Golgi apparatus, ...
Function	ATPase activity, ATPase activity, coupled to transmembrane movement of substances, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (171)    Tissues (125)    Images (38)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	171

cDNA source data(79)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(79) cDNA(79)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034720 (Evidence)
Ensembl Gene Model	ENSMUSG00000026198 (Evidence)
Entrez Gene	74104 (Evidence)
UniGene	28663
DFCI	TC1576388, TC1659941
DoTS	DT.101725997, DT.110907893, DT.533910, DT.99859064
NIA Mouse Gene Index	U021492
Consensus CDS Project	CCDS15065.1
International Mouse Knockout Project Status	Abcb6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034720	VEGA Gene Model | MGI Sequence Detail	8676	C57BL/6J
transcript	OTTMUST00000088204	VEGA | MGI Sequence Detail	2966	Not Applicable
polypeptide	OTTMUSP00000048059	VEGA | MGI Sequence Detail	842	Not Applicable

All sequences(52) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(58 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR017871	ABC transporter, conserved site
InterPro	IPR017940	ABC transporter, integral membrane type 1
InterPro	IPR003439	ABC transporter-like
InterPro	IPR001140	ABC transporter, transmembrane domain
InterPro	IPR011527	ABC transporter, transmembrane domain, type 1
Protein Ontology	PR:000003551	ATP-binding cassette sub-family B member 6, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190243 Chavan H, et al., Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR). J Biol Chem. 2012 Sep 14;287(38):32054-68
All references(40)