Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCA3
  • Mouse genes Abca3
  • Rat genes Abca3
  • Zfish genes abca3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abca3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	ABCA3	IMP		Human	PMID:26903515
Molecular Function	GO:0016887	ATP hydrolysis activity	ABCA3	IDA		Human	PMID:16959783
Molecular Function	GO:0140345	phosphatidylcholine flippase activity	ABCA3	IMP		Human	PMID:27177387
Molecular Function	GO:0140345	phosphatidylcholine flippase activity	ABCA3	IMP		Human	PMID:31473345
Molecular Function	GO:0120019	phosphatidylcholine transfer activity	ABCA3	IMP		Human	PMID:28887056
Cellular Component	GO:0097208	alveolar lamellar body	ABCA3	IDA		Human	PMID:11718719
Cellular Component	GO:0097233	alveolar lamellar body membrane	ABCA3	IDA		Human	PMID:11940594
Cellular Component	GO:0097233	alveolar lamellar body membrane	ABCA3	IDA		Human	PMID:16959783
Cellular Component	GO:0097233	alveolar lamellar body membrane	Abca3	IDA		Mouse	MGI:MGI:6478050|PMID:11940594
Cellular Component	GO:0097233	alveolar lamellar body membrane	Abca3	IDA		Mouse	PMID:14982840
Cellular Component	GO:0097233	alveolar lamellar body membrane	Abca3	IDA		Rat	PMID:11940594|RGD:1598549
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	ABCA3	IDA		Human	PMID:16959783
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	ABCA3	IDA		Human	PMID:17574245
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	ABCA3	IDA		Human	PMID:20863830
Cellular Component	GO:0005615	extracellular space	ABCA3	HDA		Human	PMID:22664934
Cellular Component	GO:0042599	lamellar body	ABCA3	IDA		Human	PMID:27177387
Cellular Component	GO:0097232	lamellar body membrane	ABCA3	IDA		Human	PMID:20863830
Cellular Component	GO:0005770	late endosome	ABCA3	IDA		Human	PMID:27177387
Cellular Component	GO:0005886	plasma membrane	ABCA3	IDA		Human	PMID:11718719
Cellular Component	GO:0005886	plasma membrane	ABCA3	IDA		Human	PMID:23137377
Biological Process	GO:0030324	lung development	Abca3	IMP		Mouse	MGI:MGI:3722561|PMID:17540762
Biological Process	GO:0030324	lung development	Abca3	IMP		Mouse	MGI:MGI:6356490|PMID:20190032
Biological Process	GO:0070925	organelle assembly	Abca3	IMP		Mouse	MGI:MGI:3722561|PMID:17540762
Biological Process	GO:0046470	phosphatidylcholine metabolic process	ABCA3	IMP		Human	PMID:17574245
Biological Process	GO:0046470	phosphatidylcholine metabolic process	ABCA3	IMP		Human	PMID:28887056
Biological Process	GO:0046470	phosphatidylcholine metabolic process	Abca3	IMP		Mouse	MGI:MGI:3709444|PMID:17267394
Biological Process	GO:0046471	phosphatidylglycerol metabolic process	Abca3	IMP		Mouse	MGI:MGI:3706225|PMID:17142808
Biological Process	GO:0046471	phosphatidylglycerol metabolic process	Abca3	IMP		Mouse	MGI:MGI:3709444|PMID:17267394
Biological Process	GO:0055091	phospholipid homeostasis	Abca3	IMP		Mouse	MGI:MGI:6356490|PMID:20190032
Biological Process	GO:0015914	phospholipid transport	ABCA3	IMP		Human	PMID:28887056
Biological Process	GO:0010875	positive regulation of cholesterol efflux	ABCA3	IMP		Human	PMID:25817392
Biological Process	GO:1902995	positive regulation of phospholipid efflux	ABCA3	IMP		Human	PMID:31473345
Biological Process	GO:2001140	positive regulation of phospholipid transport	ABCA3	IMP		Human	PMID:27177387
Biological Process	GO:0032464	positive regulation of protein homooligomerization	ABCA3	IDA		Human	PMID:27352740
Biological Process	GO:0046890	regulation of lipid biosynthetic process	Abca3	IMP		Mouse	MGI:MGI:6356490|PMID:20190032
Biological Process	GO:0032368	regulation of lipid transport	Abca3	IMP		Mouse	MGI:MGI:6356490|PMID:20190032
Biological Process	GO:0150172	regulation of phosphatidylcholine metabolic process	ABCA3	IMP		Human	PMID:25817392
Biological Process	GO:0150172	regulation of phosphatidylcholine metabolic process	ABCA3	IMP		Human	PMID:31473345
Biological Process	GO:0051384	response to glucocorticoid	Abca3	IEP		Rat	PMID:15369786|RGD:1598550
Biological Process	GO:0043129	surfactant homeostasis	Abca3	IMP		Mouse	MGI:MGI:3715384|PMID:17577581
Biological Process	GO:0043129	surfactant homeostasis	Abca3	IMP		Mouse	MGI:MGI:6295253|PMID:28034695
Biological Process	GO:0043129	surfactant homeostasis	Abca3	IMP		Mouse	MGI:MGI:3706225|PMID:17142808
Biological Process	GO:0043129	surfactant homeostasis	Abca3	IMP		Mouse	MGI:MGI:3709444|PMID:17267394
Biological Process	GO:0046618	xenobiotic export from cell	ABCA3	IMP		Human	PMID:26903515
Biological Process	GO:0006855	xenobiotic transmembrane transport	ABCA3	IMP		Human	PMID:26903515
Biological Process	GO:0042908	xenobiotic transport	ABCA3	IMP		Human	PMID:26903515

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern