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Gene Expression Data
Assay Details
Assay
Reference: J:321503 Meuser M, et al., FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development. Development. 2022 Jan 1;149(1):dev200021
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8262795
Gene symbol: Upk1b
Gene name: uroplakin 1B
Antibody: anti-Upk1b (clone 1E1; WH0007348M2)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to Alexa Fluor 555
Results
Specimen 2C +/+;Fgfr1fl/+;Fgfr2fl/+: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2+ (more )
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter basal cell of urothelium Absent 2C +/+;Fgfr1fl/+;Fgfr2fl/+ UPK1B Expression was not detected in B-cells (KRT5+deltaNP63+UPK1B-).
TS26: urothelium of ureter intermediate cell of urothelium Present 2C +/+;Fgfr1fl/+;Fgfr2fl/+ UPK1B Expression was detected in I-cells (KRT5-deltaNP63+UPK1B+).
TS26: urothelium of ureter umbrella cell of urothelium Present 2C +/+;Fgfr1fl/+;Fgfr2fl/+ UPK1B Expression was detected in S-cells (KRT5-deltaNP63-UPK1B+).
Specimen 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/+: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2+, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter basal cell of urothelium Absent 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/+ UPK1B Expression was not detected in B-cells (KRT5+deltaNP63+UPK1B-).
TS26: urothelium of ureter intermediate cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/+ UPK1B Expression was detected in I-cells (KRT5-deltaNP63+UPK1B+).
TS26: urothelium of ureter umbrella cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/+ UPK1B Expression was detected in S-cells (KRT5-deltaNP63-UPK1B+).
Specimen 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/+: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1tm5.1Sor, Fgfr2tm1Dor/Fgfr2+, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter basal cell of urothelium Absent 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/+ UPK1B Expression was not detected in B-cells (KRT5+deltaNP63+UPK1B-).
TS26: urothelium of ureter intermediate cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/+ UPK1B Expression was detected in I-cells (KRT5-deltaNP63+UPK1B+).
TS26: urothelium of ureter umbrella cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/+ UPK1B Expression was detected in S-cells (KRT5-deltaNP63-UPK1B+).
Specimen 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/fl: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1tm5.1Sor, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter umbrella cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/fl UPK1B In mutants with a complete loss of Fgfr2, the mono-layered epithelium expressed the S-cell marker UPK1B, whereas KRT5- and deltaNP63-expressing B and I cells were largely absent.
Specimen 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl left: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter umbrella cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl UPK1B left In mutants with a complete loss of Fgfr2, the mono-layered epithelium expressed the S-cell marker UPK1B, whereas KRT5- and deltaNP63-expressing B and I cells were largely absent.
Specimen 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl right: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Undilated ureter.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter umbrella cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl UPK1B right In mutants with a complete loss of Fgfr2, the mono-layered epithelium expressed the S-cell marker UPK1B, whereas KRT5- and deltaNP63-expressing B and I cells were largely absent.
Specimen 3B 12.5 control: embryonic day 12.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS20: epithelial layer of ureter Absent 3B control E12.5 UPK1B
Specimen 3B 12.5 Fgfr2cKO: embryonic day 12.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: epithelial layer of ureter Absent 3B Fgfr2cKO E12.5 UPK1B
Specimen 3B 14.5 control: embryonic day 14.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS22: urothelium of ureter Absent 3B control E14.5 UPK1B
Specimen 3B 14.5 Fgfr2cKO: embryonic day 14.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: urothelium of ureter Absent 3B Fgfr2cKO E14.5 UPK1B
Specimen 3B 15.5 control: embryonic day 15.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS23: urothelium of ureter Present 3B control E15.5 UPK1B
Specimen 3B 15.5 Fgfr2cKO: embryonic day 15.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: urothelium of ureter Present 3B Fgfr2cKO E15.5 UPK1B Expression of UPK1B occurred normally from E15.5 onwards.
Specimen 3B 16.5 control: embryonic day 16.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS24: urothelium of ureter Present 3B control E16.5 UPK1B
Specimen 3B 16.5 Fgfr2cKO: embryonic day 16.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: urothelium of ureter Present 3B Fgfr2cKO E16.5 UPK1B Expression of UPK1B occurred normally.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory