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Gene Expression Data
Assay Details
Assay
Reference: J:294282 Li L, et al., The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Cell Rep. 2019 Jul 16;28(3):698-711.e5
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7855684
Gene symbol: Tle4
Gene name: transducin-like enhancer of split 4
Results
Specimen 1E Tle4 Control: postnatal day 3; Tg(Dach1-cre)1Krs/0 (more )
Structure Cell Type Level Pattern Image Note
TS27: neocortex pyramidal neuron Present Regionally restricted 1E Tle4 Control Expression in deep layer projection neurons.
Specimen 1E Tle4 cKO: postnatal day 3; Ash2ltm1.1Bcgen/Ash2ltm1.1Bcgen, Tg(Dach1-cre)1Krs/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: neocortex Strong Regionally restricted 1E Tle4 cKO Expression upregulated and occupying a larger area compared to control.
Specimen 1F Tle4 Control: postnatal day 3; Tg(Dach1-cre)1Krs/0 (more )
Note: Triple labeled: red - Tle4; green - Bcl11b (assay MGI:7855683); gray - Cux1 (assay MGI:7855681).
Structure Cell Type Level Pattern Image Note
TS27: neocortex pyramidal neuron Present Regionally restricted 1F Control Expression in deep layer projection neurons.
Specimen 1F Tle4 cKO: postnatal day 3; Ash2ltm1.1Bcgen/Ash2ltm1.1Bcgen, Tg(Dach1-cre)1Krs/0 (more )
Note: Conditional mutant. Triple labeled: red - Tle4; green - Bcl11b (assay MGI:7855683); gray - Cux1 (assay MGI:7855681).
Structure Level Pattern Image Note
TS27: neocortex Strong Regionally restricted 1F cKO , 1F cKO inset Expression upregulated and occupying a larger area compared to control.
Specimen S1H Tle4 Control: postnatal day 7; Tg(Dach1-cre)1Krs/0 (more )
Structure Cell Type Level Pattern Image Note
TS28: neocortex pyramidal neuron Present Regionally restricted S1H Tle4 Control Expression in deep layer projection neurons.
Specimen S1H Tle4 cKO: postnatal day 7; Ash2ltm1.1Bcgen/Ash2ltm1.1Bcgen, Tg(Dach1-cre)1Krs/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: neocortex Present Regionally restricted S1H Tle4 cKO Expression comparable to control.
Specimen S2A Tle4 Control: embryonic day 12.5; Tg(Dach1-cre)1Krs/0 (more )
Note: Double labeled: green - Tle4; red - EdU.
Structure Cell Type Level Pattern Image Note
TS20: neocortex neuron Present S2A Control
Specimen S2A Tle4 cKO: embryonic day 12.5; Ash2ltm1.1Bcgen/Ash2ltm1.1Bcgen, Tg(Dach1-cre)1Krs/0 (more )
Note: Conditional mutant. Double labeled: green - Tle4; red - EdU.
Structure Cell Type Level Pattern Image Note
TS20: neocortex neuron Present S2A cKO
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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