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Ash2ltm1.1Bcgen
Targeted Allele Detail
Summary
Symbol: Ash2ltm1.1Bcgen
Name: ASH2 like histone lysine methyltransferase complex subunit; targeted mutation 1.1, Biocytogen LLC
MGI ID: MGI:7539520
Synonyms: Ash2lfl
Gene: Ash2l  Location: Chr8:26306028-26337722 bp, - strand  Genetic Position: Chr8, 14.17 cM, cytoband A3
Alliance: Ash2ltm1.1Bcgen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:294282
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting construct instructed a loxP site upstream of exon 4 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 5. Flp-mediated recombination removed the selection cassette and left exons 4 and 5 floxed. (J:294282)
Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ash2l Mutation:  43 strains or lines available
References
Original:  J:294282 Li L, et al., The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Cell Rep. 2019 Jul 16;28(3):698-711.e5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory