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Gene Expression Data
Assay Details
Assay
Reference: J:161201 Gao N, et al., Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev. 2010 Jun 15;24(12):1295-305
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7855378
Gene symbol: Lamp1
Gene name: lysosomal-associated membrane protein 1
Antibody: anti-Lamp1
Detection system: Secondary antibody
Assay notes: Two Lamp1antibodies were described, but the one used in this assay was not detailed. Anti-Lamp1 (1D4B) MGI:3758941 may have been used in this assay. Control embryos were derived from matings between Cdx2loxP/+ VillinCre+ male mice and Cdx2loxP/loxP female mice.
Results
Specimen S12a Lamp1: embryonic day 15.5; Cdx2tm1Khk/?, Tg(Vil1-cre)997Gum/? (more )
Note: Conditional mutant. Double labeled: red - Lamp1; green - Cdh1 (assay MGI:7855370).
Structure Level Pattern Image Note
TS23: intestine Present S12a Lamp1 , S12a merged
Specimen S12b Lamp1: embryonic day 15.5; Cdx2tm1Khk/?, Tg(Vil1-cre)997Gum/? (more )
Note: Conditional mutant. Double labeled: red - Lamp1; green - Cdh1 (assay MGI:7855370).
Structure Level Pattern Image Note
TS23: intestine Present S12b merged , S12b Lamp1
Specimen S1c Lamp1: embryonic day 15.5; Cdx2tm1Khk/Cdx2tm1Khk, Tg(Vil1-cre)997Gum/0 (more )
Note: Conditional mutant. Double labeled: red - Lamp1; green - Cdh1 (assay MGI:7855370).
Structure Level Pattern Image Note
TS23: intestine Present Regionally restricted S12c merged , S12c Lamp1 Authors report partially normal and partially aggregated localization of expression.
Specimen S1d Lamp1: embryonic day 15.5; Cdx2tm1Khk/Cdx2tm1Khk, Tg(Vil1-cre)997Gum/0 (more )
Note: Conditional mutant. Double labeled: red - Lamp1; green - Cdh1 (assay MGI:7855370).
Structure Level Pattern Image Note
TS23: intestine Present Regionally restricted S12d merged , S12d Lamp1 Authors report partially normal and partially aggregated localization of expression.
Specimen 5E Lamp1: embryonic day 18.5; Cdx2tm1Khk/?, Tg(Vil1-cre)997Gum/? (more )
Note: Conditional mutant. Double labeled: red - Lamp1; green - Cdh1 (assay MGI:7855370).
Structure Level Pattern Image Note
TS26: intestine Present Regionally restricted 5E Expression in lysosomes orderly situated near apical plasma membrane.
Specimen 5F Lamp1: embryonic day 18.5; Cdx2tm1Khk/Cdx2tm1Khk, Tg(Vil1-cre)997Gum/0 (more )
Note: Conditional mutant. Double labeled: red - Lamp1; green - Cdh1 (assay MGI:7855370).
Structure Level Pattern Image Note
TS26: intestine Present Regionally restricted 5F Aberrant localization of expression becomes more pronounced compared to E15.5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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