About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:174095 Cai Z, et al., Loss of shp2-mediated mitogen-activated protein kinase signaling in muller glial cells results in retinal degeneration. Mol Cell Biol. 2011 Jul;31(14):2973-83
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7788466
Gene symbol: Rcvrn
Gene name: recoverin
Results
Specimen 2F WT: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina outer nuclear layer photoreceptor cell Present 2F WT
Specimen 2F cKO: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina outer nuclear layer photoreceptor cell Present 2F cKO A 50% reduction was seen.
Specimen 2K WT: postnatal day 120 (more )
Note: Double labeled: green - Rcvrn; red - Rho (assay MGI:7788467).
Structure Cell Type Level Pattern Image Note
TS28: retina outer nuclear layer photoreceptor cell Present 2K WT
Specimen 2K cKO: postnatal day 120; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant. Double labeled: green - Rcvrn; red - Rho (assay MGI:7788467).
Structure Cell Type Level Pattern Image Note
TS28: retina outer nuclear layer photoreceptor cell Present 2K cKO Severely depleted photoreceptors (complete cell loss in some region) were seen. All layers were further reduced in thickness.
Specimen S3K: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina outer nuclear layer photoreceptor cell Present S3K
Specimen S3L: postnatal day 7; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina outer nuclear layer photoreceptor cell Present S3L Similar as in the wild-type.
Specimen not shown: postnatal day 21; Krastm4Tyj/Krastm4Tyj, Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant. Quantified in Fig 6T.
Structure Cell Type Level Pattern Image Note
TS28: retina outer nuclear layer photoreceptor cell Present Expression was restored to the wild-type level.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory