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Gene Expression Data
Assay Details
Assay
Reference: J:174095 Cai Z, et al., Loss of shp2-mediated mitogen-activated protein kinase signaling in muller glial cells results in retinal degeneration. Mol Cell Biol. 2011 Jul;31(14):2973-83
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7788451
Gene symbol: Pax6
Gene name: paired box 6
Results
Specimen 2B WT: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer amacrine cell Present 2B WT
TS28: retina inner nuclear layer amacrine cell Present 2B WT
Specimen 2B cKO: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer amacrine cell Present 2B cKO A 50% reduction was seen.
TS28: retina inner nuclear layer amacrine cell Present 2B cKO A 50% reduction was seen.
Specimen 2G WT: postnatal day 21 (more )
Note: Double labeled: green - Pax6; red - Nefm (assay MGI:7788469).
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer amacrine cell Present 2G WT
TS28: retina inner nuclear layer amacrine cell Present 2G WT
Specimen 2G cKO: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant. Double labeled: green - Pax6; red - Nefm (assay MGI:7788469).
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer amacrine cell Present 2G cKO Reduced expression compared with the control.
TS28: retina inner nuclear layer amacrine cell Present 2G cKO Reduced expression compared with the control.
Specimen 2H WT: postnatal day 21 (more )
Note: Double labeled: green - Pax6; red - B3gat1/VC1.1 (assay MGI:7788470).
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer amacrine cell Present 2H WT
TS28: retina inner nuclear layer amacrine cell Present 2H WT
Specimen 2H cKO: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant. Double labeled: green - Pax6; red - B3gat1/VC1.1 (assay MGI:7788470).
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer amacrine cell Present 2H cKO Reduced expression compared with the control.
TS28: retina inner nuclear layer amacrine cell Present 2H cKO Reduced expression compared with the control.
Specimen S3C: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer amacrine cell Present S3C
TS28: retina inner nuclear layer amacrine cell Present S3C
Specimen S3D: postnatal day 7; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer amacrine cell Present S3D Similar as in the wild-type.
TS28: retina inner nuclear layer amacrine cell Present S3D Similar as in the wild-type.
Specimen not shown: postnatal day 21; Krastm4Tyj/Krastm4Tyj, Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant. Quantified in Fig 6T.
Structure Cell Type Level Pattern Image Note
TS28: retina layer amacrine cell Present Expression was restored to the wild-type level.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/30/2025
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