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Gene Expression Data
Assay Details
Assay
Reference: J:171421 Vandunk C, et al., Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci. 2011 Apr 27;31(17):6457-67
Assay type: RNA in situ
MGI Accession ID: MGI:7660840
Gene symbol: Six6
Gene name: sine oculis-related homeobox 6
Probe: MTF#179
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Assay notes: Three possible probes were referenced: MGI:3506049, MGI:3506055 and MGI:3506054. The probe used in this assay was not specified.
Results
Specimen 1: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: suprachiasmatic nucleus Present Widespread 1_Six6 Expression was detected throughout the entire suprachiasmatic nucleus.

Specimen 6B E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: diencephalon floor plate Ambiguous Regionally restricted 6B E10.5 Six6 Expression wasn't described in the suprachiasmatic progenitor domain at E10.5.

Specimen 6B E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: diencephalon floor plate Present Regionally restricted 6B E11.5 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern.

Specimen 6B E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: diencephalon floor plate Present 6B E12.5 Six6

Specimen 6B E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: diencephalon floor plate Present 6B E13.5 Six6

Specimen 6D E11.5 Rostral 1: embryonic day 11.5 (more )
Note: Rostral-most section of a rostral-caudal series beginning from rostral eye fields level.
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted 6D E11.5 Rostral 1 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern within the entire rostrocaudal region examined.
TS19: telencephalon Present Regionally restricted 6D E11.5 Rostral 1 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern within the entire rostrocaudal region examined.

Specimen 6D E11.5 2: embryonic day 11.5 (more )
Note: Second section of a rostral-caudal series. This section contained the suprachiasmatic nucleus progenitor region.
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted 6D E11.5 2 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern within the entire rostrocaudal region examined.
TS19: telencephalon Present Regionally restricted 6D E11.5 2 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern within the entire rostrocaudal region examined.

Specimen 6D E11.5 3: embryonic day 11.5 (more )
Note: Third section of a rostral-caudal series.
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted 6D E11.5 3 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern within the entire rostrocaudal region examined.
TS19: telencephalon Present Regionally restricted 6D E11.5 3 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern within the entire rostrocaudal region examined.

Specimen 6D E11.5 4: embryonic day 11.5 (more )
Note: Fourth section of a rostral-caudal series.
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted 6D E11.5 4 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern within the entire rostrocaudal region examined.
TS19: telencephalon Present Regionally restricted 6D E11.5 4 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern within the entire rostrocaudal region examined.

Specimen 6D E11.5 Caudal 5: embryonic day 11.5 (more )
Note: Caudal-most section of a rostral-caudal series ending at developing pituitary.
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted 6D E11.5 Caudal 5 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern within the entire rostrocaudal region examined.
TS19: telencephalon Present Regionally restricted 6D E11.5 Caudal 5 Six6 Expression was first seen at E11.5 in a ventrally restricted pattern within the entire rostrocaudal region examined.

Specimen 6D E13.5 Rostral 1: embryonic day 13.5 (more )
Note: Rostral-most section of a rostral-caudal series beginning from rostral eye fields level.
Structure Level Pattern Image Note
TS21: diencephalon Present Regionally restricted 6D E13.5 Rostral 1 Six6 Expression was consistent along the rostrocaudal ventral surface.

Specimen 6D E13.5 2: embryonic day 13.5 (more )
Note: Second section of a rostral-caudal series. This section contained the suprachiasmatic nucleus progenitor region.
Structure Level Pattern Image Note
TS21: diencephalon Present Regionally restricted 6D E13.5 2 Six6 Expression was consistent along the rostrocaudal ventral surface.

Specimen 6D E13.5 3: embryonic day 13.5 (more )
Note: Third section of a rostral-caudal series. This section contained the suprachiasmatic nucleus progenitor region.
Structure Level Pattern Image Note
TS21: diencephalon Present Regionally restricted 6D E13.5 3 Six6 Expression was consistent along the rostrocaudal ventral surface.

Specimen 6D E13.5 4: embryonic day 13.5 (more )
Note: Fourth section of a rostral-caudal series. This section contained the suprachiasmatic nucleus progenitor region.
Structure Level Pattern Image Note
TS21: diencephalon Present Regionally restricted 6D E13.5 4 Six6 Expression was consistent along the rostrocaudal ventral surface.

Specimen 6D E13.5 Caudal 5: embryonic day 13.5 (more )
Note: Caudal-most section of a rostral-caudal series ending at developing pituitary.
Structure Level Pattern Image Note
TS21: diencephalon Present Regionally restricted 6D E13.5 Caudal 5 Six6 Expression was consistent along the rostrocaudal ventral surface.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory