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Gene Expression Data
Assay Details
Assay
Reference: J:291486 Daniel E, et al., Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development. Development. 2020 Feb 20;147(4):dev181560
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7623787
Gene symbol: Lamp3
Gene name: lysosomal-associated membrane protein 3
Results
Specimen S3E: embryonic day 18.5 (more )
Note: Triple labeled: green - Lamp3; white - Cdh1 (assay MGI:7623789); red - Sftpc (assay MGI:7623780).
Structure Cell Type Level Pattern Image Note
TS26: lung epithelium pulmonary alveolar type 2 cell Present S3E' , S3E'' , S3E The vast majority of AT2 cells express both Lamp3 and Sftpc.
Specimen S3F: embryonic day 18.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Note: Triple labeled: green - Lamp3; white - Cdh1 (assay MGI:7623789); red - Sftpc (assay MGI:7623780).
Structure Cell Type Level Pattern Image Note
TS26: lung epithelium pulmonary alveolar type 2 cell Present S3F' , S3F , S3F'' Cyp26b1-/- lungs had an increase in AT2 cells compared with control littermates. Co-staining of AT2 cell markers Sftpc and Lamp3 confirmed the result.
Specimen not shown +/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lung epithelium Present Regionally restricted Expression was detected in distal lung epithelium. Lamp3+ cells could be Sox9-immunopositive or Sox9-negative.
Specimen not shown -/-: embryonic day 18.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Structure Level Pattern Image Note
TS26: lung epithelium Present Regionally restricted There was an increase in Sox9+/Lamp3+ distal epithelium cells in the Cyp26b1-/- lungs. The number of Sox9-/Lamp3+ cells was not significantly changed.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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