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Gene Expression Data
Assay Details
Assay
Reference: J:291486 Daniel E, et al., Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development. Development. 2020 Feb 20;147(4):dev181560
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7623789
Gene symbol: Cdh1
Gene name: cadherin 1
Results
Specimen 4A: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: lung epithelium epithelial cell of lung Present Regionally restricted 4A Expression was detected in distal epithelial cells, which have a columnar, glandular-like structure at E15.5.
Specimen 4B: embryonic day 15.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Structure Cell Type Level Pattern Image Note
TS23: lung epithelium epithelial cell of lung Present Regionally restricted 4B Expression was detected in distal epithelial cells.
Specimen 4C: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: lung epithelium epithelial cell of lung Present Regionally restricted 4C Expression was detected in epithelial cells undergoing morphogenetic changes.
Specimen 4D: embryonic day 16.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Structure Cell Type Level Pattern Image Note
TS24: lung epithelium epithelial cell of lung Present Regionally restricted 4D Cdh1 immunolabeled epithelial cells displayed relatively normal cell rounding in the Cyp26b1-/- lungs.
Specimen 4E: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: lung epithelium epithelial cell of lung Present Regionally restricted 4E Cdh1 immunolabeled epithelial cells had a flattened, or squamous, morphology for AT1 cells and a rounded morphology for AT2 cells by E17.5.
Specimen 4F: embryonic day 17.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Structure Cell Type Level Pattern Image Note
TS25: lung epithelium epithelial cell of lung Present Regionally restricted 4F Cdh1 immunolabeled epithelial cells displayed relatively normal cell rounding in the Cyp26b1-/- lungs; however, the transition to flattened epithelium was delayed.
Specimen 4G: embryonic day 16.5 (more )
Note: Double labeled: white - Cdh1; green - Pdpn (assay MGI:7623777).
Structure Cell Type Level Pattern Image Note
TS24: lung epithelium epithelial cell of lung Present Regionally restricted 4G Expression was detected in distal epithelial cells.
Specimen 4H: embryonic day 16.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Note: Double labeled: white - Cdh1; green - Pdpn (assay MGI:7623777).
Structure Cell Type Level Pattern Image Note
TS24: lung epithelium epithelial cell of lung Present Regionally restricted 4H Expression was detected in distal epithelial cells. Defects in distal epithelial lumens were noted in the Cyp26b1-/- lungs.
Specimen S3E: embryonic day 18.5 (more )
Note: Triple labeled: white - Cdh1; green - Lamp3 (assay MGI:7623787); red - Sftpc (assay MGI:7623780).
Structure Level Pattern Image Note
TS26: lung epithelium Present S3E
Specimen S3F: embryonic day 18.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Note: Triple labeled: white - Cdh1; green - Lamp3 (assay MGI:7623787); red - Sftpc (assay MGI:7623780).
Structure Level Pattern Image Note
TS26: lung epithelium Present S3F
Specimen S3K: embryonic day 18.5 (more )
Note: Double labeled: green - Cdh1; white - Nkx2-1 (assay MGI:7623805).
Structure Level Pattern Image Note
TS26: lung epithelium Present S3K
Specimen S3L: embryonic day 18.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Note: Double labeled: green - Cdh1; white - Nkx2-1 (assay MGI:7623805).
Structure Level Pattern Image Note
TS26: lung epithelium Present S3L
Specimen S5C: embryonic day 18.5 (more )
Note: Double labeled: green - Cdh1; red - Sox2 (assay MGI:7624246).
Structure Level Pattern Image Note
TS26: lung epithelium Present S5C
Specimen S5D: embryonic day 18.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Note: Double labeled: green - Cdh1; red - Sox2 (assay MGI:7624246).
Structure Level Pattern Image Note
TS26: lung epithelium Present S5D
Specimen S6D: embryonic day 18.5 (more )
Note: Triple labeled: white - Cdh1; green - Cdh5 (assay MGI:7624322); red - Pdgfrb (assay MGI:7624321).
Structure Level Pattern Image Note
TS26: lung epithelium Present S6D
Specimen S6E: embryonic day 18.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Note: Triple labeled: white - Cdh1; green - Cdh5 (assay MGI:7624322); red - Pdgfrb (assay MGI:7624321).
Structure Level Pattern Image Note
TS26: lung epithelium Present S6E
Specimen S6L: embryonic day 18.5 (more )
Note: Triple labeled: white - Cdh1; green - Cdh5 (assay MGI:7624322); magenta - Tagln (assay MGI:7624326).
Structure Level Pattern Image Note
TS26: lung epithelium Present S6L
Specimen S6M: embryonic day 18.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Note: Triple labeled: white - Cdh1; green - Cdh5 (assay MGI:7624322); magenta - Tagln (assay MGI:7624326).
Structure Level Pattern Image Note
TS26: lung epithelium Present S6M
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory