About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:291486 Daniel E, et al., Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development. Development. 2020 Feb 20;147(4):dev181560
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7623780
Gene symbol: Sftpc
Gene name: surfactant associated protein C
Results
Specimen 3D: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: lung epithelium pulmonary alveolar type 2 cell Present 3D , 3D'
Specimen 3E: embryonic day 18.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Structure Cell Type Level Pattern Image Note
TS26: lung epithelium pulmonary alveolar type 2 cell Present 3E' , 3E Cyp26b1-/- lungs had an increase in AT2 cells compared with control littermates.
Specimen 4K: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: lung epithelium Present Regionally restricted 4K Expression was detected in AT2 progenitors.
Specimen 4L: embryonic day 16.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Structure Level Pattern Image Note
TS24: lung epithelium Present Regionally restricted 4L Immunostaining revealed no overt qualitative difference in AT2 progenitor patterning.
Specimen S3E: embryonic day 18.5 (more )
Note: Triple labeled: red - Sftpc; white - Cdh1 (assay MGI:7623789); green - Lamp3 (assay MGI:7623787).
Structure Cell Type Level Pattern Image Note
TS26: lung epithelium pulmonary alveolar type 2 cell Present S3E , S3E'' The vast majority of AT2 cells express both Lamp3 and Sftpc.
Specimen S3F: embryonic day 18.5; Cyp26b1em1Oncl/Cyp26b1em1Oncl (more )
Note: Triple labeled: red - Sftpc; white - Cdh1 (assay MGI:7623789); green - Lamp3 (assay MGI:7623787).
Structure Cell Type Level Pattern Image Note
TS26: lung epithelium pulmonary alveolar type 2 cell Present S3F , S3F'' Cyp26b1-/- lungs contain an increased in AT2 cells compared with control littermates. Co-staining with Lamp3, an additional marker of AT2 cells confirmed the result.
Specimen S4H: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: lung epithelium pulmonary alveolar type 2 cell Present S4H , S4H'
Specimen S4I: embryonic day 18.5; Cyp26b1em1Oncl/Cyp26b1em2Oncl (more )
Structure Cell Type Level Pattern Image Note
TS26: lung epithelium pulmonary alveolar type 2 cell Present S4I , S4I' There was an increase in Sftpc+ AT2 cells in the Cyp26b1-/delta10 lungs.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory