H2ax Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:309183 Gomes AL, et al., RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis. Front Cell Dev Biol. 2020;8:711
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7610727
Gene symbol:	H2ax
Gene name:	H2A.X variant histone

Antibody:	anti-phosphoH2AX (#05-636; JBW301)
Detection system:	Secondary antibody coupled to Cy3

Results

2A Ctrl ©

Specimen 2A Ctrl: embryonic day 15.5; Rint1^tm1.1Pof/Rint1^tm1.1Pof (more

)

Structure	Level	Pattern	Image	Note
TS23: retina layer	Present	Single cells	2A Ctrl

2A cKO ©

Specimen 2A cKO: embryonic day 15.5; Rint1^tm1.1Pof/Rint1^tm1.1Pof, Tg(Pax6-cre,GFP)2Pgr/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS23: retina layer	Present		2A cKO	An increased proportion of positive cells compared with the control, suggested an accumulation of endogenous DNA damage (quantified in Fig 2B).

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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