Neurod6 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:93057 Schuurmans C, et al., Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J. 2004 Jul 21;23(14):2892-902
Assay type:	RNA in situ
MGI Accession ID:	MGI:7578960
Gene symbol:	Neurod6
Gene name:	neurogenic differentiation 6

Probe:	Math2 probe
Probe preparation:	Antisense RNA

Results

Specimen 1B: embryonic day 13.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS21: cortical plate	cerebral cortex neuron	Present		1B	Expressed in early-born cortical plate neurons.
TS21: cortical preplate	cerebral cortex neuron	Present		1B	Expressed in early-born cortical plate neurons.

Specimen 1C: embryonic day 13.5; Neurog2^tm2Fgu/Neurog2^tm2Fgu (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS21: cortical plate	cerebral cortex neuron	Present		1C	Reduced expression in early-born cortical plate neurons, compared with the wild-type.
TS21: cortical preplate	cerebral cortex neuron	Present		1C	Reduced expression in early-born cortical plate neurons, compared with the wild-type.

Specimen 1D: embryonic day 13.5; Neurog1^tm1And/Neurog1^tm1And, Neurog2^tm2Fgu/Neurog2^tm2Fgu (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS21: cortical plate	cerebral cortex neuron	Present		1D	More severely reduced expression in early-born cortical plate neurons, compared with the wild-type.
TS21: cortical preplate	cerebral cortex neuron	Present		1D	More severely reduced expression in early-born cortical plate neurons, compared with the wild-type.

Specimen 1E: embryonic day 13.5; Pax6^Sey/Pax6^Sey (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS21: cortical plate	cerebral cortex neuron	Present		1E	Similar as in the wild-type.
TS21: cortical preplate	cerebral cortex neuron	Present		1E	Similar as in the wild-type.

Specimen 2I: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex intermediate zone	Present		2I
TS23: cortical plate	Present		2I

Specimen 2J: embryonic day 15.5; Neurog2^tm2Fgu/Neurog2^tm2Fgu (more

)

Structure	Level	Pattern	Image	Note
TS23: cortical plate	Present	Regionally restricted	2J	A correctly specified upper layer above distinct gaps in lower layer expression was seen.
TS23: cerebral cortex intermediate zone	Present		2J

Specimen 2K: embryonic day 15.5; Neurog1^tm1And/Neurog1^tm1And, Neurog2^tm2Fgu/Neurog2^tm2Fgu (more

)

Structure	Level	Pattern	Image	Note
TS23: cortical plate	Present	Regionally restricted	2K	A correctly specified upper layer above distinct gaps in lower layer expression was seen.
TS23: cerebral cortex intermediate zone	Present		2K

Specimen 2L: embryonic day 15.5; Ascl1^tm1And/Ascl1^tm1And, Neurog2^tm2Fgu/Neurog2^tm2Fgu (more

)

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex intermediate zone	Present	Regionally restricted	2L	Loss of expression was restricted to rostromedial domains.
TS23: cortical plate	Present	Regionally restricted	2L	Loss of expression was restricted to rostromedial domains.

Specimen 3A: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: cerebral cortex intermediate zone	Present	Uniform	3A
TS26: cortical plate	Present	Uniform	3A

Specimen 3B: embryonic day 18.5; Neurog2^tm2Fgu/Neurog2^tm2Fgu (more

)

Structure	Level	Pattern	Image	Note
TS26: cerebral cortex intermediate zone	Present	Uniform	3B	Similar as in the wild-type.
TS26: cortical plate	Present	Uniform	3B	Similar as in the wild-type.

Specimen 3C: embryonic day 18.5; Neurog1^tm1And/Neurog1^tm1And, Neurog2^tm2Fgu/Neurog2^tm2Fgu (more

)

Structure	Level	Pattern	Image	Note
TS26: cerebral cortex intermediate zone	Present		3C	Similar as in the wild-type.
TS26: cortical plate	Present		3C	Similar as in the wild-type.

Specimen 3D: embryonic day 18.5; Neurog1^tm1And/Neurog1^tm1And, Neurog2^tm2Fgu/Neurog2^tm2Fgu (more

)

Structure	Level	Pattern	Image	Note
TS26: cortical plate	Present	Regionally restricted	3D	Small superficial gaps were seen.

Specimen 6D: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex intermediate zone	Present		6D
TS23: cortical plate	Present		6D

Specimen 6E: embryonic day 15.5; Pax6^Sey/Pax6^Sey (more

)

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex intermediate zone	Present		6E	Reduced expression throughout the layer, compared with the wild-type.
TS23: cortical plate	Present		6E	Reduced expression throughout the layer, compared with the wild-type.

Specimen 6F: embryonic day 15.5; Nr2e1^tm1Rtyu/Nr2e1^tm1Rtyu, Pax6^Sey/Pax6^Sey (more

)

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex intermediate zone	Present		6F	Reduced expression throughout the layer, compared with the wild-type.
TS23: cortical plate	Present		6F	Reduced expression throughout the layer, compared with the wild-type.

Specimen 7A: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: cerebral cortex intermediate zone	Present		7A
TS26: cortical plate	Present		7A

Specimen 7B: embryonic day 18.5; Nr2e1^tm1Rtyu/Nr2e1^tm1Rtyu (more

)

Structure	Level	Pattern	Image	Note
TS26: cerebral cortex intermediate zone	Present	Regionally restricted	7B	Expression was lost in small gaps.
TS26: cortical plate	Present	Regionally restricted	7B	Expression was maintained in the upper region.

Specimen 7C: embryonic day 18.5; Pax6^Sey/Pax6^Sey (more

)

Structure	Level	Pattern	Image	Note
TS26: cortical plate	Present	Regionally restricted	7C	Expression was maintained in the upper region.
TS26: cerebral cortex intermediate zone	Trace	Regionally restricted	7C	Expression was almost completely lost in large regions.

Specimen 7D: embryonic day 18.5; Nr2e1^tm1Rtyu/Nr2e1^tm1Rtyu, Pax6^Sey/Pax6^Sey (more

)

Structure	Level	Pattern	Image	Note
TS26: cortical plate	Present	Regionally restricted	7D	Expression was maintained in the upper region.
TS26: cerebral cortex intermediate zone	Trace	Regionally restricted	7D	Expression was almost completely lost in large regions.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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