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Gene Expression Data
Assay Details
Assay
Reference: J:95889 Wines-Samuelson M, et al., Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev Biol. 2005 Jan 15;277(2):332-46
Assay type: RNA in situ
MGI Accession ID: MGI:7571568
Gene symbol: Psen1
Gene name: presenilin 1
Probe: PS1 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1C Control: embryonic day 17.5; Psen1tm2Shn/Psen1+ (more )
Structure Level Pattern Image Note
TS25: cerebral cortex Present 1C Control In control brains, transcripts were more abundant in the cortical layers than in the meningeal layer.
TS25: meninges Present 1C Control
Specimen 1C PS1 cKO: embryonic day 17.5; Psen1tm2Shn/Psen1tm2.1Shn, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: cerebral cortex Absent 1C PS1 cKO In PS1 conditional knockout brains, transcripts were eliminated in the cortical layers.
TS25: meninges Present 1C PS1 cKO Transcripts remain in the meningeal layer where Cre recombinase is not expressed.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory