About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:198483 Finelli MJ, et al., Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7529722
Gene symbol: Uchl1
Gene name: ubiquitin carboxy-terminal hydrolase L1
Antibody: anti-PGP9.5
Results
Specimen 2C PGP9.5 Control: postnatal day 1; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted 2C PGP9.5 Control Expression in cutaneous innervation of mystacial pads.
Specimen 2C PGP9.5 cKO-Nes: postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Weak Regionally restricted 2C PGP9.5 cKO-Nes Mild but significant truncated network of axons and diminished terminal arborization in upper dermis compared with controls.
Specimen S2 Control (upper): postnatal day 1; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted S2_Control (upper) Expression in cutaneous innervation of mystacial pads.
Specimen S2 cKO-Nes (upper): postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Weak Regionally restricted S2_cKO-Nes (upper) Mild but significant truncated network of axons and diminished terminal arborization in upper dermis compared with controls.
Specimen S2 Control (middle): postnatal day 1; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted S2_Control (middle) Expression in cutaneous innervation of mystacial pads.
Specimen S2 cKO-Nes (middle): postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Weak Regionally restricted S2_cKO-Nes (middle) Mild but significant truncated network of axons and diminished terminal arborization in upper dermis compared with controls.
Specimen S2 Control (lower): postnatal day 1; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted S2_Control (lower) Expression in cutaneous innervation of mystacial pads.
Specimen S2 cKO-Nes (lower): postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Weak Regionally restricted S2_cKO-Nes (lower) Mild but significant truncated network of axons and diminished terminal arborization in upper dermis compared with controls.
Specimen 3D PGP9.5 Control: postnatal day 1; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: thoracic dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 3D PGP9.5 Control
Specimen 3D PGP9.5 cKO-Nes: postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: thoracic dorsal root ganglion sensory neuron of dorsal root ganglion Present 3D PGP9.5 cKO-Nes Total number of neurons comparable to control.
Specimen S3B Control (upper): postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted S3B Control (upper) Expression in cutaneous innervation of mystacial pads.
Specimen S3B cKO-Wnt1 (upper): postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1tm1.1Abr (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Weak Regionally restricted S3B cKO-Wnt1 (upper) Number of teminal axon branches significantly decreased compared to control.
Specimen S3B Control (lower): postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted S3B Control (lower) Expression in cutaneous innervation of mystacial pads.
Specimen S3B cKO-Wnt1 (lower): postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1tm1.1Abr (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: mystacial pad Weak Regionally restricted S3B cKO-Wnt1 (lower) Number of teminal axon branches significantly decreased compared to control.
Specimen S6D PGP9.5 +/+: postnatal day 1 (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present S6D PGP9.5 +/+
Specimen S6D PGP9.5 L/L: postnatal day 1; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present S6D PGP9.5 L/L No significant difference in total number of neurons.
Specimen 7C +/+: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted 7C +/+ inset , 7C +/+ Expression in cutaneous innervation of mystacial pads.
Specimen 7C L/L: postnatal day 1; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted 7C L/L inset , 7C L/L Authors report exaggerated growth of terminal axons beyond upper dermis and into epidermis
Specimen S7A L/+ (upper): postnatal day 1; Smad1tm2Sor/Smad1+ (more )
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted S7A L/+ (upper) Expression in cutaneous innervation of mystacial pads.
Specimen S7A L/+ (lower): postnatal day 1; Smad1tm2Sor/Smad1+ (more )
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted S7A L/+ (lower) Expression in cutaneous innervation of mystacial pads.
Specimen S7A L/L (upper): postnatal day 1; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted S7A L/L (upper) Authors report longer axonal lengths in cutaneous axon network.
Specimen S7A L/L (lower): postnatal day 1; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Level Pattern Image Note
TS27: mystacial pad Present Regionally restricted S7A L/L (lower) Authors report longer axonal lengths in cutaneous axon network.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory