Casp3 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:330081 Chen S, et al., Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer Discov. 2022 Oct 5;12(10):2434-2453
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7529084
Gene symbol:	Casp3
Gene name:	caspase 3

Antibody:	anti-cleaved Caspase-3 (Asp175; #9661)
Detection system:	Secondary antibody coupled to horseradish peroxidase
Assay notes:	The antibody used recognizes the cleaved form of the protein.

Results

Specimen S9D Wild-type: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: liver	Absent		S9D wild-type

Specimen S9D Lztr1^-/-: embryonic day 15.5; Lztr1^{tm1c(EUCOMM)Wtsi}/Lztr1^{tm1c(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS23: liver	Present	Widespread	S9D Lztr1^-/-

Specimen S9D Rit1^-/-: embryonic day 15.5; Rit1^tm1.1Fmcc/Rit1^tm1.1Fmcc (more

)

Structure	Level	Pattern	Image	Note
TS23: liver	Absent		S9D Rit1^-/-

Specimen S9D Lztr1^-/-;Rit1^-/-: embryonic day 15.5; Lztr1^{tm1c(EUCOMM)Wtsi}/Lztr1^{tm1c(EUCOMM)Wtsi}, Rit1^tm1.1Fmcc/Rit1^tm1.1Fmcc (more

)

Structure	Level	Pattern	Image	Note
TS23: liver	Absent		S9D Lztr1^-/-;Rit1^-/-	The Rit1 deletion in this mutant rescued the profound cell death seen in fetal livers of Lztr1-/- mutants.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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