Rit1^tm1.1Fmcc
Targeted Allele Detail

Summary

• Symbol: Rit1^tm1.1Fmcc
• Name: Ras-like without CAAX 1; targeted mutation 1.1, Frank McCormick
• MGI ID: MGI:6323555
• Synonyms: RIT1^M90I
• Gene: Rit1 Location: Chr3:88624154-88638354 bp, + strand Genetic Position: Chr3, 38.95 cM, cytoband F1
• Alliance: Rit1^tm1.1Fmcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274577
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector contains an FRT-flanked neo, exons 4 through 6 of the Rit1 gene immediately followed by a STOP cassette, a polyadenylation sequence, a F3-site flanked PURO cassette, sequence for exon 4 and mutant exon 5 (containing the M90I point mutation). Flp-mediated recombination removed the FRT-flanked neo cassette. The M90I mutation is associated with a mutation found in patients with Noonan syndrome. (J:274577)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rit1 Mutation: 18 strains or lines available

References

• Original: J:274577 Castel P, et al., RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science. 2019 Mar 15;363(6432):1226-1230
• All: 2 reference(s)