About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:299026 Kannan-Sundhari A, et al., Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival. Front Cell Dev Biol. 2020;8:576654
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7470864
Gene symbol: Ctbp2
Gene name: C-terminal binding protein 2
Results
Specimen 3B Brd4+/+ P14: postnatal day 14 (more )
Note: Double labeled: red - Ctbp2; green - Gria2 (assay MGI:7470876) and Gria3 (assay MGI:7470879).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B +/+ P14 Merge , 3B +/+ P14 Ctbp2 Expression is in presynaptic ribbons in inner hair cells.
Specimen 3B Atoh1-Brd4-/- P14: postnatal day 14; Brd4tm1c(EUCOMM)Wtsi/Brd4tm1c(EUCOMM)Wtsi, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Double labeled: red - Ctbp2; green - Gria2 (assay MGI:7470876) and Gria3 (assay MGI:7470879).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B Atoh1-Brd4-/- P14 Ctbp2 , 3B Atoh1-Brd4-/- P14 Merge This mutant has reduced numbers of intact synapses compared to controls.
Specimen 3B Brd4+/+ P16: postnatal day 16 (more )
Note: Double labeled: red - Ctbp2; green - Gria2 (assay MGI:7470876) and Gria3 (assay MGI:7470879).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B +/+ P16 Ctbp2 , 3B +/+ P16 Merge Expression is in presynaptic ribbons in inner hair cells.
Specimen 3B Atoh1-Brd4-/- P16: postnatal day 16; Brd4tm1c(EUCOMM)Wtsi/Brd4tm1c(EUCOMM)Wtsi, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Double labeled: red - Ctbp2; green - Gria2 (assay MGI:7470876) and Gria3 (assay MGI:7470879).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B Atoh1-Brd4-/- P16 Merge , 3B Atoh1-Brd4-/- P16 Ctbp2 This mutant has reduced numbers of intact synapses compared to controls.
Specimen 3B Brd4+/+ P21: postnatal day 16 (more )
Note: Double labeled: red - Ctbp2; green - Gria2 (assay MGI:7470876) and Gria3 (assay MGI:7470879).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B +/+ P21 Ctbp2 , 3B +/+ P21 Merge Expression is in presynaptic ribbons in inner hair cells.
Specimen 3B Atoh1-Brd4-/- P21: postnatal day 16; Brd4tm1c(EUCOMM)Wtsi/Brd4tm1c(EUCOMM)Wtsi, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Double labeled: red - Ctbp2; green - Gria2 (assay MGI:7470876) and Gria3 (assay MGI:7470879).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B Atoh1-Brd4-/- P21 Merge , 3B Atoh1-Brd4-/- P21 Ctbp2 This mutant has reduced numbers of intact synapses compared to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory