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Gene Expression Data
Assay Details
Assay
Reference: J:235650 Mao H, et al., Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS Genet. 2016 Sep;12(9):e1006282
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7425185
Gene symbol: Trp53
Gene name: transformation related protein 53
Antibody: anti-p53
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 8A: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Level Pattern Image Note
TS21: neocortex Absent 8A
Specimen 8B: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+, Magohtm1c(KOMP)Dlsi/Magoh+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Present 8B Significant expression in ventricular zone compared to control
Specimen 8C: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Level Pattern Image Note
TS20: neocortex Absent 8C
Specimen 8D: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: cerebral cortex ventricular layer Present 8D Significant expression in ventricular zone compared to control
Specimen 8E: embryonic day 11.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Level Pattern Image Note
TS19: telencephalon Absent 8E
Specimen 8F: embryonic day 11.5; Emx1tm1(cre)Krj/Emx1+, Rbm8atm1Dlsi/Rbm8a+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: telencephalon ventricular layer Present 8F Expression prior to onset of apoptosis.
Specimen 8G: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Level Pattern Image Note
TS20: neocortex Absent 8G
Specimen 8H: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rbm8atm1Dlsi/Rbm8a+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: cerebral cortex ventricular layer Present 8H Significant expression in ventricular zone compared to control
Specimen 8I: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+ (more )
Note: Double labeled: green - P53 (Trp53); red - Pax6 (assay MGI:7425182).
Structure Level Pattern Image Note
TS20: neocortex Absent 8I
Specimen 8J: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rbm8atm1Dlsi/Rbm8a+ (more )
Note: Conditional mutant. Double labeled: green - P53 (Trp53); red - Pax6 (assay MGI:7425182).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex ventricular layer neural stem cell Present Regionally restricted 8J Expression specifically enriched in Pax6-expressing neural stem cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory