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Gene Expression Data
Assay Details
Assay
Reference: J:235650 Mao H, et al., Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS Genet. 2016 Sep;12(9):e1006282
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7425182
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti-Pax6
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2G: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Cell Type Level Pattern Image Note
TS20: neocortex neural stem cell Present 2G
Specimen 2I: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Weak Regionally restricted 2I Density of expressing cells significantly reduced compared to controls.
Specimen 2Q,2S: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Pax6; red - CC3 (Casp3 assay MGI:7425184).
Structure Level Pattern Image Note
TS20: neocortex Present 2S , 2Q
Specimen 8I: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+ (more )
Note: Double labeled: red - Pax6; green - P53 (Trp53 assay MGI:7425185).
Structure Level Pattern Image Note
TS20: neocortex Present 8I
Specimen 8J: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rbm8atm1Dlsi/Rbm8a+ (more )
Note: Conditional mutant. Double labeled: red - Pax6; green - P53 (Trp53 assay MGI:7425185).
Structure Level Pattern Image Note
TS20: neocortex Present 8J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory