About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:235650 Mao H, et al., Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS Genet. 2016 Sep;12(9):e1006282
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7425184
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-CC3
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2O: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Level Pattern Image Note
TS20: neocortex Ambiguous 2O
Specimen 2P: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Strong 2P Extensive expression in neocortex.
Specimen 2Q,2S: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - CC3 (Casp3); green - Pax6 (assay MGI:7425182).
Structure Cell Type Level Pattern Image Note
TS20: neocortex cerebral cortex neuron Present Regionally restricted 2S , 2Q Expression in both neurons and neural stem cells throughout dorsal cortex.
TS20: neocortex neural stem cell Present Regionally restricted 2S , 2Q Expression in both neurons and neural stem cells throughout dorsal cortex.
Specimen 2R,2T: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - CC3 (Casp3); green - Tuj1 (Tubb3 assay MGI:7425183).
Structure Cell Type Level Pattern Image Note
TS20: neocortex cerebral cortex neuron Present Regionally restricted 2T , 2R Expression in both neurons and neural stem cells throughout dorsal cortex.
TS20: neocortex neural stem cell Present Regionally restricted 2T , 2R Expression in both neurons and neural stem cells throughout dorsal cortex.
Specimen S7B: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Level Pattern Image Note
TS20: neocortex Ambiguous S7B
Specimen S7C: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rbm8atm1Dlsi/Rbm8a+, Trp53tm1Brn/Trp53+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Present S7C
Specimen S7D: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rbm8atm1Dlsi/Rbm8a+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Ambiguous S7D Authors report complete rescue of apoptosis.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory