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Gene Expression Data
Assay Details
Assay
Reference: J:235650 Mao H, et al., Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS Genet. 2016 Sep;12(9):e1006282
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7425184
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-CC3
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2O: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Level Pattern Image Note
TS20: neocortex Ambiguous 2O
Specimen 2P: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Strong 2P Extensive expression in neocortex.
Specimen 2Q,2S: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - CC3 (Casp3); green - Pax6 (assay MGI:7425182).
Structure Cell Type Level Pattern Image Note
TS20: neocortex cerebral cortex neuron Present Regionally restricted 2S , 2Q Expression in both neurons and neural stem cells throughout dorsal cortex.
TS20: neocortex neural stem cell Present Regionally restricted 2S , 2Q Expression in both neurons and neural stem cells throughout dorsal cortex.
Specimen 2R,2T: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - CC3 (Casp3); green - Tuj1 (Tubb3 assay MGI:7425183).
Structure Cell Type Level Pattern Image Note
TS20: neocortex cerebral cortex neuron Present Regionally restricted 2T , 2R Expression in both neurons and neural stem cells throughout dorsal cortex.
TS20: neocortex neural stem cell Present Regionally restricted 2T , 2R Expression in both neurons and neural stem cells throughout dorsal cortex.
Specimen S7B: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Level Pattern Image Note
TS20: neocortex Ambiguous S7B
Specimen S7C: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rbm8atm1Dlsi/Rbm8a+, Trp53tm1Brn/Trp53+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Present S7C
Specimen S7D: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Rbm8atm1Dlsi/Rbm8a+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Ambiguous S7D Authors report complete rescue of apoptosis.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory