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Gene Expression Data
Assay Details
Assay
Reference: J:219823 Rosin JM, et al., Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination. Dev Biol. 2015 Mar 1;399(1):54-67
Assay type: RNA in situ
MGI Accession ID: MGI:7336391
Gene symbol: Shh
Gene name: sonic hedgehog
Probe: Shh cDNA3
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 4A/A': postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebellum Purkinje cell layer Present 4A , 4A'
TS27: cerebellum vermis lobule Present 4A , 4A'
Specimen 4B/B': postnatal day 0; Shox2tm1Ddu/Shox2tm1.1Ddu, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebellum Purkinje cell layer Present Regionally restricted 4B' , 4B Expression was down-regulated in Purkinje cells in the vermis, particularly in dorsalresiding Purkinje cells in the central lobe and posterior lobe.
TS27: cerebellum vermis lobule Present Regionally restricted 4B' , 4B Expression was down-regulated in Purkinje cells in the vermis, particularly in dorsalresiding Purkinje cells in the central lobe and posterior lobe.
Specimen not shown: postnatal day 1 (more )
Note: Summarized in Fig 4M.
Structure Cell Type Level Pattern Image Note
TS27: cerebellum Purkinje cell layer Purkinje cell Present
TS27: cerebellum vermis lobule Purkinje cell Present
Specimen not shown: postnatal day 1; Shox2tm1Ddu/Shox2tm1.1Ddu, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Summarized in Fig 4M.
Structure Cell Type Level Pattern Image Note
TS27: cerebellum Purkinje cell layer Purkinje cell Present Regionally restricted Expression was down-regulated in Purkinje cells in the vermis, particularly in dorsalresiding Purkinje cells in the central lobe and posterior lobe.
TS27: cerebellum vermis lobule Purkinje cell Present Regionally restricted Expression was down-regulated in Purkinje cells in the vermis, particularly in dorsalresiding Purkinje cells in the central lobe and posterior lobe.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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