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Shh cDNA3 Probe Detail
Nucleotide
Probe/Clone
  • Name
    Shh cDNA3
  • Sequence Type
    cDNA
  • ID
    MGI:1327804
  • Region Covered
    3' end of exon 1, all of exon 2 and the 5' end of exon 3 (nucleotides 200-850)
  • Vector Type
    Plasmid
  • Insert Site
    HindIII
  • Insert Size
    0.64kb
  • Note
    In J:38196, the author used EcoRI site instead of HindIII.
Source
  • Species
    mouse, laboratory
  • Age
    embryonic day 8.5
Genes
Shh sonic hedgehog
Expression
  • Assay Results
    393
References
J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
J:19895 Ang SL, et al., HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994 Aug 26;78(4):561-74
J:21617 Gunther T, et al., Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Development. 1994 Nov;120(11):3119-30
J:29671 Bitgood MJ, et al., Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol. 1995 Nov;172(1):126-38
J:30345 Haramis AG, et al., The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5' HoxD genes during limb pattern formation. Development. 1995 Dec;121(12):4237-45
J:35170 Abud HE, et al., Ectopic expression of Fgf-4 in chimeric mouse embryos induces the expression of early markers of limb development in the lateral ridge. Dev Genet. 1996;19(1):51-65
J:35345 Ema M, et al., Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis. Mol Cell Biol. 1996 Oct;16(10):5865-75
J:38196 Masuya H, et al., Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Dev Biol. 1997 Feb 1;182(1):42-51
J:51128 Qu S, et al., Physical and genetic interactions between Alx4 and Cart1. Development. 1999 Jan;126(2):359-69
J:54600 Zhang Y, et al., Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev Dyn. 1999 May;215(1):45-53
J:56108 Kitajima K, et al., Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds. Dev Dyn. 1999 Jul;215(3):206-14
J:73507 Heyer J, et al., Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12595-600
J:59923 Tole S, et al., Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev Biol. 2000 Jan 15;217(2):254-65
J:64180 Outram SV, et al., Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity. 2000 Aug;13(2):187-97
J:65195 Stoykova A, et al., Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J Neurosci. 2000 Nov 1;20(21):8042-50
J:76826 Zuniga A, et al., Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis. Mech Dev. 2002 Jun;114(1-2):51
J:78220 Zhang Z, et al., Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development. 2002 Sep;129(17):4135-46
J:79899 Grotewold L, et al., The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly. Dev Biol. 2002 Nov 1;251(1):129-41
J:86666 Michno K, et al., Shh expression is required for embryonic hair follicle but not mammary gland development. Dev Biol. 2003 Dec 1;264(1):153-65
J:86841 Elms P, et al., Zic2 is required for neural crest formation and hindbrain patterning during mouse development. Dev Biol. 2003 Dec 15;264(2):391-406
J:87318 Ohazama A, et al., Traf6 is essential for murine tooth cusp morphogenesis. Dev Dyn. 2004 Jan;229(1):131-5
J:88784 Petryk A, et al., The mammalian twisted gastrulation gene functions in foregut and craniofacial development. Dev Biol. 2004 Mar 15;267(2):374-86
J:92327 Adamska M, et al., En1 and Wnt7a interact with Dkk1 during limb development in the mouse. Dev Biol. 2004 Aug 1;272(1):134-44
J:104611 Moore-Scott BA, et al., Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs. Dev Biol. 2005 Feb 15;278(2):323-35
J:104154 Rice R, et al., Expression patterns of Hedgehog signalling pathway members during mouse palate development. Gene Expr Patterns. 2006 Jan;6(2):206-12
J:106405 Mackay DR, et al., The mouse Ovol2 gene is required for cranial neural tube development. Dev Biol. 2006 Mar 1;291(1):38-52
J:110714 Barrionuevo F, et al., Sox9 is required for notochord maintenance in mice. Dev Biol. 2006 Jul 1;295(1):128-40
J:114714 DeLaurier A, et al., Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb. Dev Biol. 2006 Nov 1;299(1):22-34
J:119866 Bort R, et al., Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev Biol. 2006 Feb 1;290(1):44-56
J:119875 Lebel M, et al., Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain. Dev Biol. 2007 Feb 1;302(1):345-55
J:134435 Anselme I, et al., Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes. Dev Biol. 2007 Apr 1;304(1):208-20
J:138715 Li WY, et al., Signaling through Tgf-beta type I receptor Alk5 is required for upper lip fusion. Mech Dev. 2008 Sep-Oct;125(9-10):874-82
J:139570 Capellini TD, et al., Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. Dev Biol. 2008 Sep 15;321(2):500-14
J:259785 Evangelista M, et al., Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction. Sci Signal. 2008 Sep 30;1(39):ra7
J:148693 Narimatsu M, et al., Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 2009 Apr 17;137(2):295-307
J:150375 Cobourne MT, et al., Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome. Dev Biol. 2009 Jul 1;331(1):38-49
J:153731 Pazin DE, et al., Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation. Dev Dyn. 2009 Nov;238(11):2877-90
J:199568 Neufeld SJ, et al., mRNA fluorescence in situ hybridization to determine overlapping gene expression in whole-mount mouse embryos. Dev Dyn. 2013 Sep;242(9):1094-100
J:202865 Yang T, et al., Prickle1 stunts limb growth through alteration of cell polarity and gene expression. Dev Dyn. 2013 Nov;242(11):1293-306
J:223183 Yang T, et al., Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations. Mol Genet Genomic Med. 2014 Mar;2(2):138-51
J:219823 Rosin JM, et al., Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination. Dev Biol. 2015 Mar 1;399(1):54-67
J:264204 Deimling SJ, et al., Genetic interaction between Gli3 and Ezh2 during limb pattern formation. Mech Dev. 2018 Jun;151:30-36
J:268103 Dykes IM, et al., A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity. Sci Rep. 2018 Jul 11;8(1):10439
J:306252 Tissieres V, et al., Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits. Cell Rep. 2020 Apr 7;31(1):107490
J:326160 Hintermann A, et al., Developmental and evolutionary comparative analysis of a regulatory landscape in mouse and chicken. Development. 2022 Jun 15;149(12):dev200594
J:338194 Sulic AM, et al., Transcriptomic landscape of early hair follicle and epidermal development. Cell Rep. 2023 Jun 13;42(6):112643

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory