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Gene Expression Data
Assay Details
Assay
Reference: J:309372 Padgett LR, et al., Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development. FASEB J. 2021 May;35(5):e21473
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7329929
Gene symbol: Cpa1
Gene name: carboxypeptidase A1, pancreatic
Antibody: carboxypeptidase A1/CPA1 antibody (AF2765)
Detection system: Secondary antibody
Results
Specimen 2B Ptf1a-cre: postnatal week 5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Triple labeled: blue - Cpa1; green - Gcg (assay MGI:7329928); red - Ins1 (assay MGI:7329925) and Ins2 (assay MGI:7329927).
Structure Cell Type Level Pattern Image Note
TS28: exocrine pancreas pancreatic acinar cell Present 2B Ptr1a-cre
Specimen 2B Dhps PANC (left): postnatal week 5; Dhpstm1.1Mirm/Dhpstm1.1Mirm, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Triple labeled: blue - Cpa1; green - Gcg (assay MGI:7329928); red - Ins1 (assay MGI:7329925) and Ins2 (assay MGI:7329927).
Structure Cell Type Level Pattern Image Note
TS28: exocrine pancreas pancreatic acinar cell Absent 2B Dhps deltaPANC (left)
Specimen 2B Dhps PANC (right): postnatal week 5; Dhpstm1.1Mirm/Dhpstm1.1Mirm, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Triple labeled: blue - Cpa1; green - Gcg (assay MGI:7329928); red - Ins1 (assay MGI:7329925) and Ins2 (assay MGI:7329927).
Structure Cell Type Level Pattern Image Note
TS28: exocrine pancreas pancreatic acinar cell Absent 2B Dhps deltaPANC (right)
Specimen 3C: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: red - Cpa1; green - Ins1 (assay MGI:7329925) and Ins2 (assay MGI:7329927).
Structure Level Pattern Image Note
TS22: pancreas Present 3C
Specimen 3D: embryonic day 14.5; Dhpstm1.1Mirm/Dhpstm1.1Mirm, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: red - Cpa1; green - Ins1 (assay MGI:7329925) and Ins2 (assay MGI:7329927).
Structure Level Pattern Image Note
TS22: pancreas Present 3D No significant difference in pancreas area between mutants and controls
Specimen 3I: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: red - Cpa1; green - phospho-histone H3.
Structure Level Pattern Image Note
TS22: pancreas Present 3I
Specimen 3J: embryonic day 14.5; Dhpstm1.1Mirm/Dhpstm1.1Mirm, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: red - Cpa1; green - phospho-histone H3.
Structure Level Pattern Image Note
TS22: pancreas Present 3J
Specimen 4A: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: pancreas Present 4A
Specimen 4B: embryonic day 14.5; Eif5atm1.1Tlm/Eif5atm1.1Tlm, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: pancreas Present 4B No significant difference in pancreas area between mutants and controls
Specimen 4J: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: blue - Cpa1; green - Sox9 (assay MGI:7329933).
Structure Level Pattern Image Note
TS22: pancreas Present 4J
Specimen 4K: embryonic day 14.5; Eif5atm1.1Tlm/Eif5atm1.1Tlm, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: blue - Cpa1; green - Sox9 (assay MGI:7329933).
Structure Level Pattern Image Note
TS22: pancreas Present 4K
Specimen S3A: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: red - Cpa1; green - Sox9 (assay MGI:7329933).
Structure Level Pattern Image Note
TS22: pancreas Present S3A
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory