Dhps^tm1.1Mirm
Targeted Allele Detail

Summary

• Symbol: Dhps^tm1.1Mirm
• Name: deoxyhypusine synthase; targeted mutation 1.1, Raghavendra Mirmira
• MGI ID: MGI:6402162
• Synonyms: Dhps^loxP
• Gene: Dhps Location: Chr8:85798386-85801791 bp, + strand Genetic Position: Chr8, 41.55 cM
• Alliance: Dhps^tm1.1Mirm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286192
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was introduced to intron 1 and an FRT-loxP-neo-FRT-loxP cassette was placed in intron 7. Flp-mediated recombination removed the FRT-flanked neo cassette (J:286192)

Expression

In Mice Carrying this Mutation:

45 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dhps Mutation: 21 strains or lines available

Notes

ES cells = BA1

References

• Original: J:286192 Levasseur EM, et al., Hypusine biosynthesis in beta cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis. Sci Signal. 2019 Dec 3;12(610)
• All: 5 reference(s)